4 unknown, 3 completed. 2 Phase 3, 2 Phase 4, 1 Early Phase 1, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 2 | Unknown 2 |
| Phase 4 | 2 | Completed 2 |
| Early Phase 1 | 1 | Unknown 1 |
| Not applicable | 1 | Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Bromhexine: new trials by email Literature Review of Bromhexine trials Research Report on Bromhexine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community FluvoxaMINE Maleate 50 MG, Fluvoxamine, Bromhexine, Fluvoxamine, Cyproheptadine - Treatment Efficacy | Phase 4 | Completed | Chulalongkorn University | 1200 | 2021-10-01 | 2022-11-04 |
| Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19 Vitamin C, N-acetylcysteine (NAC), NAC + Bromhexine (BMX) - COVID-19 | Phase 3 | Unknown | Universidade Federal do Ceara | 219 | 2021-07-15 | 2021-06-30 |
| Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals Hydroxychloroquine Sulfate, Bromhexine 8 MG - Hydroxychloroquine, Antimalarials | Early Phase 1 | Unknown | Instituto Nacional de Rehabilitacion | 214 | 2021-02-01 | 2021-06-29 |
| Study on the Pharmacokinetics of Bromine Hexane Hydrochloride Tablets in Healthy Adults Bromhexine Hydrochloride Tablet - Pharmacokinetics | Phase 1 | Completed | Second Affiliated Hospital of Wenzhou Medical University | 33 | 2020-12-28 | 2025-05-16 |
| BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization Bromhexine and Spironolactone, Base therapy - COVID 19 | Phase 3 | Unknown | Lomonosov Moscow State University Medical Research and Educational Center | 80 | 2020-05-16 | 2020-06-09 |
| Prevention of Infection and Incidence of COVID-19 in Medical Personnel Assisting Patients With New Coronavirus Disease Bromhexine Hydrochloride - Increased Risk of SARS-CoV-2 Infection | Phase 4 | Completed | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | 50 | 2020-05-14 | 2022-04-13 |
| Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets Combined With Standard Treatment/ Standard Treatment in Patients With Suspected and Mild Novel Coronavirus Pneumonia (COVID-19) Bromhexine Hydrochloride Tablets, Arbidol Hydrochloride Granules, Recombinant Human Interferon α2b Spray - Novel Coronavirus Pneumonia, 2019-nCoV | Not applicable | Unknown | Second Affiliated Hospital of Wenzhou Medical University | 18 | 2020-02-16 | 2020-05-01 |
COVID-19 (4) · Coronavirus Infections (1) · Pneumonia, Viral (1) · Respiratory Tract Infections (1)
Second Affiliated Hospital of Wenzhou Medical University (2) · Chulalongkorn University (1) · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health (1) · Instituto Nacional de Rehabilitacion (1) · Lomonosov Moscow State University Medical Research and Educational Center (1) · Universidade Federal do Ceara (1)
China (2) · Russia (2) · Brazil (1) · Mexico (1) · Thailand (1)
Cameron Hurst, PhD (1) · Dhammika Leshan Wannigama, MD PhD (1) · Evgeny Mikhaylov, MD, PhD (1) · Julio Granados-Montiel, MD, PhD (1) · Kanokpoj Chanpiwat, MD (1) · Katika Akksilp, MD (1) · Shuichi Abe, MD (1)
PMID 18945956, PMID 25321315, PMID 27183377, PMID 28621712, PMID 32020029, PMID 32091533, PMID 32094336, PMID 32109013, PMID 32142651, PMID 32150618, PMID 32167747, PMID 32228809, PMID 32294342, PMID 32379955, PMID 32475230, PMID 33108255, PMID 33155953, PMID 33519466, PMID 33558079, PMID 34344672, PMID 35103059, PMID 38516100