14 trials newly registered in Digestive System Diseases, first posted 2026-10-21, by therapeutic area, largest first. All areas.
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study of AHB-121 in Healthy Participants and Chronic Hepatitis B (CHB) Participants AHB-121, Placebo - Chronic Hepatitis B Virus | Phase 1 | Not yet recruiting | Ausper Biopharma Co., Ltd. | 110 | 2026-10-28 | 2026-10-21 |
| A Study of the Safety and Efficacy of Prime Editing (PM647a) in Participants With Alpha-1 Antitrypsin Deficiency PM647a - Alpha-1 Antitrypsin Deficiency, Alpha-1 Antitrypsin Deficiency-associated Lung Disease | Phase 1 / Phase 2 | Not yet recruiting | Prime Medicine, Inc. | 54 | 2026-10-01 | 2026-10-21 |
| Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks No intervention; observational assessment only - Obesity & Overweight, Diabetes Mellitus, Type 2 | Not yet recruiting | Shanxi Bethune Hospital | 25974 | 2026-11-01 | 2026-10-21 | |
| Cold Water Papillary Irrigation Plus Rectal NSAIDs vs Rectal NSAIDs Alone for Post-ERCP Pancreatitis (COLD) Cold water irrigation of the papilla, Rectal NSAID (diclofenac 100 mg) - Post ERCP Pancreatitis, Acute Pancreatitis (AP) | Not applicable | Not yet recruiting | University Hospital Virgen de las Nieves | 250 | 2026-11-01 | 2026-10-21 |
| Fruquintinib Combined With Capecitabine as Adjuvant Extended Therapy After R0 Resection and Perioperative Chemotherapy in Patients With Liver-Only Metastatic Colorectal Cancer Fruquintinib Combined With Capecitabine, Follow-up observation - Colorectal Cancer | Phase 3 | Not yet recruiting | West China Hospital | 140 | 2026-10-08 | 2026-10-21 |
| Assessment of Nutritional Status in Celiac Disease Using Muscle Ultrasound in Pediatric Patients. performing muscle ultrasonography on patients - Celiac Disease in Children, Nutritional Assessment | Not applicable | Enrolling by invitation | Ondokuz Mayıs University | 120 | 2026-08-03 | 2026-10-21 |
| AI-SC Multi-center Study evaluate the alignment between AI-SC recommendations and LT-SC decisions, Multi AI-SC model - Liver Cirrhosis | Active not recruiting | University Health Network, Toronto | 1000 | 2026-04-01 | 2026-10-21 | |
| Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy - Chronic Anal Fissure | Not applicable | Completed | Sheikh Zayed Federal Postgraduate Medical Institute | 72 | 2026-06-15 | 2026-10-21 |
| Hasson Versus Veress Access With Umbilical Versus Epigastric Gallbladder Extraction in Laparoscopic Cholecystectomy Hasson open access and umbilical gallbladder extraction, Veress needle access and epigastric gallbladder extraction - Cholelithiasis, Symptomatic Gallstone Disease | Not applicable | Completed | Sedat Tan | 58 | 2019-09-20 | 2026-10-21 |
| PULSAR Radiotherapy Combined With Immunotherapy for High-Risk Advanced Liver Cancer PULSAR (Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy), Immune checkpoint inhibitor-based therapy - Hepatocellular Carcinoma (HCC), Radiotherapy-Induced Immune Priming | Phase 2 | Recruiting | Samsung Medical Center | 38 | 2026-10-15 | 2026-10-21 |
| PERCE-MUCO: Perceptions and Expectations of People With Cystic Fibrosis Regarding a Change in Treatment Cystic Fibrosis (CF) | Recruiting | Fondation Ildys | 343 | 2026-07-09 | 2026-10-21 | |
| Safety of Anticoagulation Therapy in Cirrhotic Patients With PVT and Severe Thrombocytopenia Anticoagulation Therapy - Thrombocytopenia Related to Chronic Liver Disease, Anticoagulation Treatment | Completed | Qilu Hospital of Shandong University | 304 | 2025-09-01 | 2026-10-21 | |
| Incidental Gallbladder Carcinoma :Incidence and Clinical Significance in Specimens From Routine Cholecystectomies in Sohag Locality histopathology of gall bladder - Gall Bladder Carcinoma | Recruiting | Sohag University | 100 | 2026-09-20 | 2026-10-21 | |
| Lucid BE Biomarkers Study Tissue - Barrett's Esophagus, Barrett's Esophagus With Dysplasia | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2026-12-01 | 2026-10-21 |