Corneal Trauma Diagnostic Study

NCT07887425 — Not applicable, Recruiting, 40 participants, InnSight Technology, Inc.

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Tear Fluid Collection in Patients Before and After Corneal Incision or Trauma.

Registry	NCT07887425
Status	Recruiting
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, diagnostic
Enrollment	40 (Estimated)
Sponsor	InnSight Technology, Inc. (Industry)
Conditions	Ocular Trauma
Interventions	Tear fluid collection with mass spec analysis. (Diagnostic test)
Dates	start 2026-11-01 (estimated), primary completion 2027-11-01 (estimated), completion 2027-11-01 (estimated), first posted 2026-10-21, last updated 2026-10-21
Locations	1 site in United States

-Summary

Tear fluid will be collected from patients diagnosed with ocular trauma at the University of Pittsburgh Medical Center to evaluate biomarkers.

Expand all sections · Collapse all

+Detailed description

Prospective, controlled, single-site, clinical trial evaluating tear fluid biomarkers in patients diagnosed with eye trauma at the University of Pittsburgh.

+Arms and interventions

Arm	Type	Interventions	Description
Patients with ocular trauma	Experimental	Diagnostic Test: Tear fluid collection with mass spec analysis.

Tear fluid collection with mass spec analysis. (Diagnostic test): Tear fluid collection with mass spec analysis.

+Outcome measures

Primary outcomes

Primary Outcome - Ascorbic Acid [One year.]: Measurement of ascorbic acid using mass spec

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Minimum age of 18 years.
* Diagnosis of visually significant cataract and scheduled for routine cataract surgery at UPMC with a clear corneal incision or
* scheduled for clinical repair of a full-thickness corneal laceration.

Exclusion Criteria:

* Prior history of full-thickness corneal laceration from trauma or from a surgical procedure
* Current diagnosis of glaucoma or use of ocular hypotensive drops or oral aqueous suppressants.
* Actively being treated for the diagnosis of dry eyes with a topical drop other than artificial tears.
* Actively taking oral or topical supplementation of Vitamin C.
* Scheduled for additional eye surgeries, combined with the routine cataract surgery.
* Surgical plan that would include incisions in the clear for cataract extraction.
* Inability to provide informed consent due to suspected head trauma, altered mental status, or other factors impairing decision-making capacity.

+Locations (1)

Facility	City	Country	Status
UPMC Vision Insititute - Mercy Pavilion	Pittsburgh, Pennsylvania	United States	Recruiting