| Registry | NCT07886671, acronym DEWPOINT |
|---|---|
| Status | Not yet recruiting |
| Study type | Observational |
| Enrollment | 89 (Estimated) |
| Sponsor | Unity Health Toronto (Other) |
| Conditions | Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning, Spontaneous Breathing Trial |
| Dates | start 2026-11-01 (estimated), primary completion 2028-10-31 (estimated), completion 2028-11-30 (estimated), first posted 2026-10-21, last updated 2026-10-21 |
| Locations | 1 site in Canada |
Related Papers Related Patents Related Grants Related Experts
All trials for Weaning-induced Pulmonary Edema All trials for Mechanical Ventilation Weaning
Critically ill patients who require a breathing machine are routinely assessed with a spontaneous breathing trial (SBT) to determine if they can safely breathe on their own. If the trial fails, the breathing machine must be continued. One common cause is weaning-induced pulmonary oedema (WIPO), in which the heart cannot handle the increased workload during spontaneous breathing, causing fluid to accumulate in the lungs. Although several markers can suggest WIPO, it is often diagnosed after the SBT has already failed. Earlier recognition could allow clinicians to treat the condition promptly, improving the success rate of subsequent trials.
This study will examine whether electrical impedance tomography (EIT)-a bedside monitor that tracks how air moves in the lungs-can help identify WIPO earlier. We will focus on how lung aeration changes in the first minutes of the trial and whether combining EIT with standard clinical measurements improves early prediction of SBT outcome and identification of WIPO.
Study procedures will take place during routine SBTs and are mostly non-invasive. Participants will undergo EIT monitoring, heart and lung ultrasound, ventilator measurements, and blood tests. Clinical care remains entirely according to the ICU team. Participants will be followed for up to 28 days.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| All study participants | Monitoring during a spontaneous breathing trial |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: * Patients aged 18 years and older * Patients admitted to an intensive care unit (ICU) * Patients who are intubated and mechanically ventilated for at least 48 hours * Patients at increased risk for WIPO, defined as meeting either of the following: 1. Presence of known clinical risk factors, including known cardiac dysfunction (defined as dilated, hypertrophic, or hypokinetic cardiopathy or significant valvular disease), COPD, obesity, or metabolic syndrome (three out of hypertension, obesity, high cholesterol, high triglycerides, and diabetes) 2. Evidence of weaning failure, defined as ≥1 failed SBT, or ≥1 failed extubation (requiring re-intubation or tracheostomy within 7 days) Exclusion Criteria: * Patients who have contraindications to EIT monitoring (for example, implanted electrical cardiac devices and chest wall lesions obstructing the application of the EIT belt)
| Facility | City | Country | Status |
|---|---|---|---|
| St. Michael's Hospital | Toronto, Ontario | Canada |