Long Term Outcome After Use of Vacuum-induced Tamponade for Postpartum Hemorrhage at a Single Tertiary Center
| Registry | NCT07885072, acronym LOVIT |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Enrollment | 380 (Estimated) |
| Sponsor | University of Zurich (Other) |
| Conditions | Postpartum Hemorrhage, Treatment Outcome, Pregnancy Outcome |
| Dates | start 2026-10-01, primary completion 2027-10-01 (estimated), completion 2027-10-01 (estimated), first posted 2026-10-21, last updated 2026-10-21 |
| Locations | 1 site in Switzerland |
Related Papers Related Patents Related Grants Related Experts
All trials for Postpartum Hemorrhage All trials for Treatment Outcome
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period (2017-2025). By combining hospital data with follow-up patient questionnaires, it will provide new information on reproductive outcomes and contribute to the evaluation of the long-term safety profile of vacuum-induced tamponade.
Postpartum hemorrhage (PPH) is the leading cause of maternal morbidity and mortality worldwide. When first-line medical treatments fail, uterine tamponade is an established second-line intervention. Vacuum-induced tamponade is a relatively new method that offers rapid uterine collapse and bleeding control, and has shown good short-term effectiveness.
Long-term outcomes following vacuum-induced tamponade have not been studied. Specifically, to our knowledge no data exists on its impact on fertility, subsequent pregnancies, or potential complications such as intrauterine adhesions.
Since most women affected by PPH are of reproductive age, this information is highly relevant for clinical care and patient counseling for the following family plan.
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period. By combining hospital data with follow-up patient questionnaires, it will provide new information on reproductive outcomes and contribute to the evaluation of the long-term safety profile of vacuum-induced tamponade.
The results may help to guide future clinical decisions, improve patient information, and contribute to the broader evaluation of long-term effects of vacuum-induced tamponade in obstetric practice.
The objective of this project is to descriptively assess the occurrence of secondary infertility in women who underwent vacuum-induced tamponade for postpartum hemorrhage at the University Hospital of Zurich between January 2017 until December 2025.
As long-term reproductive outcomes after VIT have not previously been systematically investigated, this study is primarily exploratory and hypothesis-generating.
The findings will provide preliminary estimates of fertility-related outcomes, including secondary infertility and time to conception, and will serve as a basis for the design, sample size calculation, and feasibility assessment of future prospective studies.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Women to have received vacuum induced tamponade during 2017-2025 |
Sex: Female, ages: 18 Years to any
Inclusion Criteria: * Women ≥ 18 years of age. * Delivery at the USZ between January 2017 and December 2025. Documented postpartum hemorrhage managed with VIT. * Provision of written informed consent Exclusion Criteria: * Decline of informed consent. * Inability to establish contact (e.g., incorrect address, telephone number not reachable, moved abroad). * Women who are unable to provide informed consent (e.g., due to language barriers without translation support, or cognitive impairment).
| Facility | City | Country | Status |
|---|---|---|---|
| University Hospital Zurich, Department of Obstetrics | Zurich, Canton of Zurich | Switzerland | Recruiting |