The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control as Measured by Continuous Glucose Monitoring
| Registry | NCT07829042 |
|---|---|
| Status | Not yet recruiting |
| Phase | Not applicable |
| Study type | Interventional; randomized, crossover, masking: none, prevention |
| Enrollment | 12 (Estimated) |
| Sponsor | University of California, San Francisco (Other) |
| Conditions | Glucose Control |
| Interventions | High Intensity Interval Training, Moderate Intensity aerobic training (Other) |
| Dates | start 2026-09-15 (estimated), primary completion 2026-10-15 (estimated), completion 2026-10-20 (estimated), first posted 2026-09-18, last updated 2026-09-22 |
| Locations | 1 site in United States |
Related Papers Related Patents Related Grants Related Experts
All trials for Glucose Control All trials of High Intensity Interval Training All trials of Moderate Intensity aerobic training
This study will be conducted as a prospective, randomized crossover trial evaluating non-diabetic and pre-diabetic adults ($n=12$) continuously monitored with Dexcom G7 continuous glucose monitors over an 11-day period. Participants will complete two distinct exercise protocols in a randomized sequence: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT). Primary outcome metrics will focus on mean glucose levels and time in range (TIR, defined as $\\le 120\\text{ mg/dL}$) recorded throughout each active exercise block and its associated recovery window. To evaluate the comparative efficacy of the two modalities, paired within-subject differences will be statistically analyzed against pre-specified non-inferiority margins set at $3\\text{ mg/dL}$ for mean glucose, as well as a primary $3$-point and secondary $5$-point margin for time in range.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Moderate Intensity Exercise | Experimental | Other: Moderate Intensity aerobic training | Five consecutive days of moderate intensity aerobic exercise |
| High Intensity Exercise | Active comparator | Other: High Intensity Interval Training | One session High-Intensity Interval training |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: Age 18 years or older Non-diabetic or pre-diabetic status (defined by medical history or standard screening criteria, e.g., HbA1c < 6.5%) Capable and willing to participate in both Zone 2 aerobic exercise and high-intensity interval training (HIIT) protocols Willing to wear a continuous glucose monitor (Dexcom G7) continuously for the 11-day study duration Able to provide written informed consent Exclusion Criteria: Diagnosis of Type 1 or Type 2 diabetes Use of glucose-lowering medications, insulin, or other pharmaceuticals that significantly alter glucose metabolism Current skin conditions, allergies, or sensitivities to medical-grade adhesives that prevent continuous glucose monitor placement Musculoskeletal, cardiovascular, or neurological conditions that contraindicate vigorous exercise or high-intensity interval training Pregnant or planning to become pregnant during the study period Concurrent participation in another clinical trial or interventional exercise study
| Facility | City | Country | Status |
|---|---|---|---|
| University of California, San Francisco | San Francisco, California | United States |