Effects of Interrupting Prolonged Sitting With Different Standing Intervals on Vascular Health in Women

NCT07802574 — Not applicable, Completed, 21 participants, King Saud University

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Registry	NCT07802574
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: none, basic science
Enrollment	21 (Actual)
Sponsor	King Saud University (Other)
Conditions	Prolonged Sitting, Vascular Health, Sedentary Behavior
Interventions	Short Standing Interval, Continuous Standing Interval, Intermittent Standing Interval (Behavioral)
Dates	start 2026-04-02, primary completion 2026-05-20, completion 2026-05-20, first posted 2026-09-03, last updated 2026-10-09
Locations	1 site in Saudi Arabia

-Summary

The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. The main questions it aims to answer are:

Does interrupting prolonged sitting with short standing intervals (10 minutes every hour) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? Does interrupting prolonged sitting with prolonged intermittent standing intervals (30 minutes every hour divided into three 10-minute standing bouts) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)?

The researcher will compare three different sitting interruption conditions to evaluate their effects on vascular health outcomes:

Standing for 10 minutes every hour. Continuous standing for 30 minutes every hour. Intermittent standing for 30 minutes every hour divided into three 10-minute standing bouts.

Participants will:

Attend three experimental sessions in random order separated by at least 7 days.

Complete 3 hours of sitting with different standing interruption protocols. Undergo measurements of blood pressure, pulse wave velocity, and heart rate before sitting and after each hour of the experiment.

Undergo height, weight, and body mass index measurements.

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+Arms and interventions

Arm	Type	Interventions	Description
Short Standing Interval	Experimental	Behavioral: Short Standing Interval	Participants will complete 3 hours of sitting interrupted with 10 minutes of standing every hour.
Continuous Standing Interval	Experimental	Behavioral: Continuous Standing Interval	Participants will complete 3 hours of sitting interrupted with 30 continuous minutes of standing every hour.
Intermittent Standing Interval	Experimental	Behavioral: Intermittent Standing Interval	Participants will complete 3 hours of sitting interrupted with 30 minutes of standing every hour divided into three 10-minute standing bouts.

Short Standing Interval (Behavioral): Participants will interrupt prolonged sitting with 10 minutes of standing every hour during 3 hours of sitting.
Continuous Standing Interval (Behavioral): Participants will interrupt prolonged sitting with 30 continuous minutes of standing every hour during 3 hours of sitting.
Intermittent Standing Interval (Behavioral): Participants will interrupt prolonged sitting with 30 minutes of standing every hour divided into three 10-minute standing bouts during 3 hours of sitting.

+Outcome measures

Primary outcomes

Blood Pressure [Baseline, 1 hour, 2 hours, and 3 hours]: Systolic and diastolic blood pressure will be measured before sitting and after each hour during the experimental sessions.
Pulse Wave Velocity [Baseline, 1 hour, 2 hours, and 3 hours]
Heart Rate [Baseline, 1 hour, 2 hours, and 3 hours]

+Eligibility

Sex: Female, ages: 18 Years to 45 Years, accepts healthy volunteers

Inclusion Criteria:

* Female participants aged 18-45 years.
* Healthy individuals with normal blood pressure levels (systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg).
* Body mass index (BMI) less than 30 kg/m².
* Ability to stand without support.
* No history of cardiovascular disease or chronic diseases that may affect study outcomes.

Exclusion Criteria:

* Pregnancy or breastfeeding.
* Back injuries preventing prolonged sitting.
* Use of medications that may affect cardiovascular responses, including antihypertensive, antidiabetic, antidepressant, or hormonal medications.
* Presence of chronic diseases or cardiovascular conditions affecting vascular health.

+Locations (1)

Facility	City	Country	Status
King Saud University	Riyadh	Saudi Arabia

+Investigators

Abdullah B Alansare, PhD, Study chair, King Saud University