| Registry | NCT07796269 |
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| Status | Not yet recruiting |
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| Study type | Observational |
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| Enrollment | 72 (Estimated) |
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| Sponsor | University of Nebraska (Other) |
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| Conditions | Wound Healing |
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| Interventions | tooth extraction (Procedure) |
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| Dates | start 2026-11-01 (estimated), primary completion 2028-11-01 (estimated), completion 2030-11-01 (estimated), first posted 2026-09-01, last updated 2026-09-14 |
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| Locations | 1 site in United States |
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Related Papers Related Patents Related Grants Related Experts
All trials for Wound Healing All trials of tooth extraction
-Summary
Patients presenting to the University of Nebraska Medical Center College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid (GCF) and saliva sampling and a blood draw. Following atraumatic tooth extraction, the subjects will be reevaluated for healing at 1, 2-weeks and 3 months. At each appointment, GCF, saliva and wound fluid (WF) will be collected and at 3 months a second xray will be taken.
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+Arms and interventions
- tooth extraction (Procedure): posterior tooth extraction
+Outcome measures
Primary outcomes
- Amount of Interleukin-1 beta (IL1-B) in gingival crevicular at baseline [Baseline]: Measurement of IL1B in GCF
Secondary outcomes
- Bone Density [3 months]: Change in bone density post-extraction
+Eligibility
Sex: All, ages: 65 Years to 80 Years
Inclusion Criteria:
* needs posterior tooth extracted
* no systemic conditions or meds affecting wound healing
* non-smoker
Exclusion Criteria:
* systemic conditions or meds known to affect wound healing
* smokers
+Locations (1)
| Facility | City | Country | Status |
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| University of Nebraska Medical Center College of Dentistry | Lincoln, Nebraska | United States | |
+Publications
- Dignam P, Elshafey M, Jeganathan A, Foo M, Park JS, Ratnaweera M. Prevalence and Factors Influencing Post-Operative Complications following Tooth Extraction: A Narrative Review. Int J Dent. 2024;2024:7712829. Epub 20240509. doi: 10.1155/2024/7712829. PubMed PMID: 38756385; PMCID: PMC11098612. 2. Khalid KA, Nawi AFM, Zulkifli N, Barkat MA, Hadi H. Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. Life (Basel). 2022;12(12). Epub 20221219. doi: 10.3390/life12122142. PubMed PMID: 36556508; PMCID: PMC9784880. 3. Martin P, Pardo-Pastor C, Jenkins RG, Rosenblatt J. Imperfect wound healing sets the stage for chronic diseases. Science. 2024;386(6726):eadp2974. Epub 20241206. doi: 10.1126/science.adp2974. PubMed PMID: 39636982. 4. Amler MH. Age factor in human alveolar bone repair. J Oral Implantol. 1993;19(2):138-42. PubMed PMID: 8246300. 5. Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018;97(13):1424-30. Epub 20180803. doi: 10.1177/0022034518792567. PubMed PMID: 30075090; PMCID: PMC6854267. 6. Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S. Current Knowledge on the Healing of the Extraction Socket: A Narrative Review. Bioengineering (Basel). 2023;10(10). Epub 20230929. doi: 10.3390/bioengineering10101145. PubMed PMID: 37892875; PMCID: PMC10604628. 7. Sims NA. Influences of the IL-6 cytokine family on bone structure and function. Cytokine. 2021;146:155655. Epub 20210728. doi: 10.1016/j.cyto.2021.155655. PubMed PMID: 34332274. 8. Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and Chemokines in Periodontitis. Eur J Dent. 2020;14(3):483-95. Epub 20200623. doi: 10.1055/s-0040-1712718. PubMed PMID: 32575137; PMCID: PMC7440949. 9. Razavi P, Rezaee SA, Akhondian S, Asgari N, Fatemi K, Mohajertehran F. Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of