Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts

NCT07767227 — Recruiting, 30 participants, Translational Genomics Research Institute

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Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts

Registry	NCT07767227
Status	Recruiting
Study type	Observational
Enrollment	30 (Estimated)
Sponsor	Translational Genomics Research Institute (Other); collaborators: Hoag Memorial Hospital Presbyterian, City of Hope National Medical Center, Piedmont Healthcare
Conditions	Pancreatic Cyst
Dates	start 2025-02-03, primary completion 2027-12-01 (estimated), completion 2028-03-01 (estimated), first posted 2026-08-17, last updated 2026-08-17
Locations	2 sites in United States

-Summary

The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins.

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+Arms and interventions

Arm	Type	Interventions	Description
Pancreatic cyst			Patients who are or will be scheduled for surgical resection of their worrisome pancreatic cyst as part of their clinically indicated care.

+Outcome measures

Primary outcomes

Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors [At enrollment]

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures.
* Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol.
* Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated.
* Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm.

Exclusion Criteria:

* Patient who is pregnant at the time of study enrollment and sample collection.
* Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm.
* Patient is unwilling or unable to provide informed consent or comply with study procedures.

+Locations (2)

Facility	City	Country	Status
Hoag Family Cancer Institute	Newport Beach, California	United States	Recruiting
Piedmont HealthCare	Atlanta, Georgia	United States	Recruiting

+Investigators

Michael Demeure, MD, Principal investigator, Hoag Family Cancer Institute

My Notes

Public

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