Nailfold Capillaroscopic Changes in Psoriasis

NCT07693595 — Recruiting, 100 participants, Al-Azhar University

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Nailfold Capillaroscopic Changes in Psoriasis and Its Correlation With Disease Severity

Registry	NCT07693595
Status	Recruiting
Study type	Observational
Enrollment	100 (Estimated)
Sponsor	Al-Azhar University (Other)
Conditions	Psoriasis
Interventions	Nailfold Capillaroscopy (Other)
Dates	start 2026-08-01 (estimated), primary completion 2026-11-01 (estimated), completion 2026-12-01 (estimated), first posted 2026-07-09, last updated 2026-07-31
Locations	1 site in Egypt

-Summary

The goal of this observational study is to evaluate nailfold capillaroscopic changes in patients with psoriasis and to assess their correlation with disease severity. The study will also explore differences in capillaroscopic findings across different clinical types of psoriasis and skin phototypes (Fitzpatrick classification). The study will include patients diagnosed with psoriasis attending dermatology outpatient clinics. Participants will undergo clinical assessment and nailfold capillaroscopy to detect microvascular changes.

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+Arms and interventions

Nailfold Capillaroscopy (Other), also known as Dermoscopy (if used for nails): Participants will undergo nailfold capillaroscopy using a USB digital capillaroscope to assess microvascular changes in psoriatic patients. Clinical assessment including PASI score and evaluation of nail involvement will also be performed.

+Outcome measures

Primary outcomes

Nailfold capillaroscopic abnormalities in psoriasis patients [Baseline]: Detection and description of nailfold capillaroscopic (NFC) abnormalities in patients with psoriasis.

Secondary outcomes

Variation of nailfold capillaroscopic findings among different clinical types of psoriasis and correlation with disease severity (PASI score). [Baseline]: Correlation between PASI score and presence of NFC changes. \- Comparison of nailfold capillaroscopic findings in different types of psoriasis

+Eligibility

Sex: All

Inclusion Criteria:

* Patients clinically diagnosed with psoriasis.

Exclusion Criteria:

* Patients with connective tissue diseases (e.g., systemic sclerosis, SLE)
* Diabetes mellitus or peripheral vascular disease
* Current smokers
* Pregnant or lactating women
* Recent use of vasodilators or beta-blockers
* Manual workers exposed to vibrating tools

+Locations (1)

Facility	City	Country	Status
Al-Hussein University Hospital & Sayed Galal University Hospital	Cairo, Cairo Governorate	Egypt	Recruiting