Physical Exercise During the Cancer Care Pathway

NCT07652502 — Not yet recruiting, 370 participants, Fondazione Policlinico Universitario Agostino Gemelli IRCCS

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Registry	NCT07652502, acronym ECOLE
Status	Not yet recruiting
Study type	Observational
Enrollment	370 (Estimated)
Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Other)
Conditions	Cancer, Treatment-Related, Cancer, Oncology, Oncologic Disorders
Dates	start 2026-06-15 (estimated), primary completion 2026-12-15 (estimated), completion 2027-10-30 (estimated), first posted 2026-06-17, last updated 2026-06-26
Locations	2 sites in France, Romania

-Summary

Background: Physical exercise is proven safe and effective in improving quality of life and reducing treatment-related side effects in oncology. However, patient adherence to international guidelines remains suboptimal. Investigating the knowledge, attitudes, and practices (KAP) regarding physical activity is crucial to identifying unmet educational needs and barriers.

Objective: This multicenter, cross-sectional observational study (ECOLE project) aims to assess KAP levels concerning exercise among cancer patients and explore the correlations between KAP scores and sociodemographic or clinical variables.

Methods: Over a 6-month period, an anonymous online survey (Microsoft Forms) will be administered to adult cancer patients (≥18 years old) at any disease or treatment stage. A minimum sample size of 370 participants is targeted. Statistical analyses will include Descriptive Statistics, Exploratory and Confirmatory Factor Analyses to validate KAP scales, and Multivariable Logistic Regression to identify predictors of adherence (≥150 minutes/week) and perceived barriers or facilitators.

Expected Results: The study will provide a comprehensive overview of physical activity perceptions and behaviors in oncology. These insights will support the design of targeted educational interventions and structured exercise programs, contributing to the development of a novel "Exercise Oncology Specialist" within supportive care teams.

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+Outcome measures

Primary outcomes

physical exercise in cancer patients. [1 day]: To evaluate the level of knowledge, attitudes, and practices (KAP) related to physical by administering the study survey exercise in cancer patients.

Secondary outcomes

safety of physical exercise oncology [1 day]: Determine the level of knowledge regarding the benefits and safety of physical exercise by administering the study survey.
self-efficacy regarding exercise oncology [1 day]: Evaluate attitudes, perceptions, and self-efficacy regarding physical activity by administering the study survey.
relationship between exercise oncology and oncological journey [1 day]: Analyze the potential relationship between knowledge, attitudes, and the practice of physical exercise
demographic and clinical variables in exercise oncology [1 day]: Explore the role of demographic and clinical variables (e.g., age, sex, tumor type, phase of treatment) by administering the study questionnaire.
barriers and facilitators to exercise oncology [1 day]: Identify potential barriers and facilitators to the practice of physical exercise by administering the study questionnaire.
interest of cancer patients in exercise oncology [1 day]: Assess the interest of cancer patients in structured physical exercise programs by administering the study questionnaire.

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Age ≥18 years
* Oncological diagnosis
* Ability to understand the language of the respective country of origin
* Electronic informed consent

Exclusion Criteria:

\- Failure to accept the informed consent

+Locations (2)

Facility	City	Country	Status
Institut Rafael	Paris	France
Universitatea Alexandru Ioa Cuza din Iasi	Iași	Romania

+Investigators

Stefano Magno, Principal investigator, Fondazione Policlinico Universitario Agostino Gemelli IRCCS