From Stroke Rehabilitation to Independence: An Impairment-Aware Control Framework for Adaptive Exoskeleton Assistance
| Registry | NCT07616167 |
|---|---|
| Status | Not yet recruiting |
| Phase | Not applicable |
| Study type | Interventional; randomized, crossover, masking: none, treatment |
| Enrollment | 20 (Estimated) |
| Sponsor | University of Michigan (Other) |
| Conditions | Stroke |
| Interventions | Unified Control Framework for Lower-Limb Powered Orthosis, Conventional Robotic Controller (Device) |
| Dates | start 2026-10-01 (estimated), primary completion 2027-12-31 (estimated), completion 2027-12-31 (estimated), first posted 2026-06-01, last updated 2026-06-01 |
| Locations | 1 site in United States |
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All trials for Stroke All trials of Unified Control Framework for Lower-Limb Powered Orthosis All trials of Conventional Robotic Controller
The goal of this clinical trial is to test a new, impairment-aware robotic control software framework to see if its smart adaptation can improve walking recovery in healthy adults and chronic stroke survivors. .
The main questions it aims to answer are:
Can the new control software safely use sensors and machine learning to predict and instantly adapt to a user's specific walking needs?
Does training with a robotic device driven by this new adaptive control framework improve walking speed and overall mobility in stroke survivors?
Researchers will compare a lower-limb orthosis operating under the new "smart" control software (which adapts to the user's impairment) to the same device operating under a standard, non-adaptive controller (which uses rigid or fixed assistance) to see if the new control approach leads to greater improvements in walking ability.
Participants will:
Walk on treadmills, flat walkways, or stairs while wearing a robotic leg orthosis driven by the different control software systems being tested.
Wear small tracking tools (like reflective motion-capture markers and muscle activity sensors) so researchers can precisely measure how their movements interact with each control program.
Complete standard walking tests to measure their walking speed and overall mobility under each software condition.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Experimental Arm | Experimental | Device: Unified Control Framework for Lower-Limb Powered Orthosis | Training with the new "unified control framework" (the smart, adaptive robotic exoskeleton). |
| Active Comparator Arm | Active comparator | Device: Conventional Robotic Controller | Training with a "conventional controller" (the standard robotic exoskeleton controller). |
Sex: All, ages: 18 Years to 80 Years, accepts healthy volunteers
Inclusion Criteria: * Cohort 1: Able-Bodied Participants (Initial Validation) * Healthy young adults. * No history of neurological, orthopedic, or cardiovascular impairments affecting gait or balance. * Able to walk independently without assistive devices. Cohort 2: Stroke Survivors (Clinical Efficacy Pilot) * Individuals with a documented history of chronic stroke. * Persistent unilateral lower-limb motor impairment resulting in a pathological gait pattern (heterogeneous gait deficits). * Stable medical condition allowing for participation in intensive physical rehabilitation tasks. * Able to provide informed consent. Exclusion Criteria: * Severe cognitive or communication impairments that prevent the participant from following safety instructions or reporting discomfort. * Co-existing neurological conditions (other than stroke) that independently impair locomotion (e.g., Parkinson's disease, Multiple Sclerosis). * Severe lower-limb joint contractures or orthopedic conditions that mechanically restrict the safe range of motion of the robotic orthosis. * Skin breakdowns, open wounds, or severe unhealed lesions at the contact points where the powered orthosis interfaces with the lower limbs. * Any medical contraindication to intensive walking exercise or treadmill training (e.g., unstable angina, severe unmanaged cardiovascular disease).
| Facility | City | Country | Status |
|---|---|---|---|
| Rehabilitation Laboratory in the Ford Robotics Building on the University of Michigan North Campus | Ann Arbor, Michigan | United States |