Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function

NCT07614685 — Recruiting, 20 participants, University of Rochester

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Registry	NCT07614685, acronym PROOF
Status	Recruiting
Study type	Observational
Enrollment	20 (Estimated)
Sponsor	University of Rochester (Other)
Conditions	Breathing, Lung Function Decreased, MRI Imaging, Healthy
Interventions	Airway Oscillometer, Phase Resolved Functional Lung MRI (Device, diagnostic test)
Dates	start 2026-09-01, primary completion 2027-07-01 (estimated), completion 2028-01-01 (estimated), first posted 2026-05-29, last updated 2026-09-11
Locations	1 site in United States

-Summary

This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.

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+Arms and interventions

Arm	Type	Interventions	Description
All participants		Device: Airway Oscillometer; Diagnostic Test: Phase Resolved Functional Lung MRI

Airway Oscillometer (Device): The termoflo c-100 Airwave Oscillometer System is intended to measure respiratory system impedance using the Forced Oscillation Technique (FOT).
Phase Resolved Functional Lung MRI (Diagnostic test): The Phase Resolved Functional Lung (PREFUL) MRI technique acquires images of the lung so that measures of ventilatory defect percentage can be calculated.

+Outcome measures

Primary outcomes

Oscillometer [Single measurement, approximately 1 day]: The oscillometer will collect an airway impedance measurement which is made up of multiple variables.
Phase Resolved Functional Lung (PREFUL) MRI [Single measurement, approximately 1 day]: PREFUL MRI will acquire images of the lungs and a measurement called the ventilatory defect percentage (or VDP) will be calculated.

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Age 18 years or older
* Ability to provide consent
* Willingness to perform MRI and breathing test
* Must be able to speak and understand English

Exclusion Criteria:

* Pregnant
* Unable or willing to provide consent or perform the required maneuvers for testing.

+Locations (1)

Facility	City	Country	Status
University of Rochester Medical Center	Rochester, New York	United States	Recruiting