Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh

NCT07541742 — Not yet recruiting, 240 participants, University of Copenhagen

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Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh: A Cohort Study

RegistryNCT07541742, acronym AQUAFOOD
StatusNot yet recruiting
Study typeObservational
Enrollment240 (Estimated)
SponsorUniversity of Copenhagen (Other); collaborators: Noakhali Science and Technology University, Bangladesh Agricultural University (BAU), University of Stirling, University of Aberdeen, International Centre for Diarrhoeal Disease Research, Bangladesh
ConditionsNutritional Status, Micronutrient Status, Omega 3 Fat Status, Diet Diversity, Markers of Inflammation, Climate Adaptation, Climate Change Awareness
InterventionsThe follow-up aims to evaluate natural changes occurring from adolescence to young adulthood with respect to the study objectives due to lifestyle and environmental factors, without any intervention. (Other)
Datesstart 2026-04-15 (estimated), primary completion 2026-08-05 (estimated), completion 2026-12-10 (estimated), first posted 2026-04-21, last updated 2026-05-06
Locations1 site in Bangladesh

Related Papers Related Patents Related Grants Related Experts
All trials for Nutritional Status All trials for Micronutrient Status All trials of The follow-up aims to evaluate natural changes occurring from adolescence to young adulthood with respect to the study objectives due to lifestyle and environmental factors, without any intervention.

-Summary

This study aims to examine how societal and climate changes influence the nutritional status and fish consumption of young women over a 10 year period in southern Bangladesh, and how these factors affect their children's health. A cohort of 240 adolescents first studied in 2017 will be followed to assess changes in their dietary patterns, nutritional status, climate perceptions and mitigation practices, as well as the nutritional status of their children aged 6 months to 5 years.

The study in 2017 sampled 60 adolescent girls in each of four rural communities, plus a semi-rural community around a fish processing plant, representing in total 5 communities. Of these 60 X 5 = 300 girls, the current study follows up the individuals in the rural communities representing a cohort of 240.

Bangladesh faces high rates of adolescent malnutrition, with many girls married before 18 and suffering from chronic nutrient deficiencies. These issues have long-term impacts on health, productivity, and intergenerational well-being. By linking the fisheries and aquaculture sector, a key to Bangladesh's economy with public health and nutrition, this research aims to guide targeted policies for vulnerable coastal communities.

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+Detailed description

Aquatic foods are fundamental to the Bangladeshi diet, providing nearly two-thirds of total animal protein. Despite this, malnutrition remains a severe public health crisis with a complex etiology. Bangladesh faces a double burden of malnutrition, marked by persistently high rates of micronutrient deficiencies affecting roughly half of both pregnant and non-pregnant women alongside rising levels of overweight and obesity. These challenges are further exacerbated by substantial intrahousehold inequities in this patriarchal society. Disempowerment and early marriage disproportionately expose adolescent girls and young women to inadequate nutrient intake and poor health outcomes, perpetuating an intergenerational cycle of malnutrition. Furthermore, chronic undernutrition and stunting continue to affect a large proportion of children under five.

The problem is particularly acute in coastal communities, where climate change impacts such as salinity intrusion and extreme weather compromise food production and dietary diversity. Understanding and improving the dietary and nutritional status of adolescent girls and young women is therefore essential to breaking the cycle of poor health and ensuring long-term population well-being. Building on a 2017 study conducted with a cohort of 240 adolescents, this research aims to provide longitudinal insights into how nutritional status, female autonomy, aquatic food consumption, and dietary practices have influenced the health and well-being of these women and their children nearly after 10 years.

Hypotheses

1. Nutritional status, fish consumption, and female autonomy during adolescence (2017) influence the nutritional status of young women in 2026 and that of their offspring.
2. Fish consumption is positively associated with biological markers (omega-3 fatty acids, vitamin D levels, and stable isotope ratios in hair).

Objectives

1. To assess changes in nutritional status, fish intake, socioeconomic factors, and female autonomy among young women from 2017 to 2026, and examine their associations with the nutritional status of their children (6 months-5 years).
2. To investigate associations between assessed fish consumption and biological markers (omega-3, vitamin D, and stable isotope ratios in hair).

The study will be conducted in four distinct saline gradient agro-ecological zones across the shrimp-prawn farming regions of southwest Bangladesh, specifically in Fakirhat (Bagerhat District), Dumuria and Paikgacha (Khulna District), and Shyamnagor (Satkhira District).

+Arms and interventions

ArmTypeInterventionsDescription
Follow-up of adolescent girls from 2017 to 2026Other: The follow-up aims to evaluate natural changes occurring from adolescence to young adulthood with respect to the study objectives due to lifestyle and environmental factors, without any intervention.The cohort of adolescent girls enrolled in 2017 at ages 12-16 will be followed up in 2026 to assess changes in their socioeconomic status, nutritional status, dietary intake, and women empowerment, and to examine how these factors are associated with the nutritional status of their children aged 6 months-5 years.
  • The follow-up aims to evaluate natural changes occurring from adolescence to young adulthood with respect to the study objectives due to lifestyle and environmental factors, without any intervention. (Other): There is no intervention

+Outcome measures

Primary outcomes

  • Omega-3 status [One sampling point between April and August 2026]: Eicosapentaenoic acid (EPA) in whole blood (% of total fatty acid)
  • Omega-3 status [One sampling point between April and August 2026]: Docosahexaenoic acid (DHA) in whole blood (% of total fatty acid)
  • Micronutrient status [One sampling point between April and August 2026]: Vitamin D (total 25-hydroxyvitamin D) concentration in blood, nmol/L
  • Micronutrient status [One sampling point between April and August 2026]: Hemoglobin concentration in blood (g/dL)
  • Micronutrient status [One sampling point between April and August 2026]: Ferritin concentration in blood (µg/L)
  • Inflammation status [One sampling point between April and August 2026]: C-reactive protein concentration in blood (mg/L)
  • Inflammation status [One sampling point between April and August 2026]: Alpha-1-acid glycoprotein concentration in blood (g/L)

Secondary outcomes

  • Nutritional status [One measurement between April and August 2026]: Height (cm)
  • Nutritional status [One measurement between April and August 2026]: Weight (kg)
  • Nutritional status [One measurement between April and August 2026]: Mid-upper arm circumference (cm)
  • Nutritional status [Between April and August 2026]: Body mass index (kg/m\^2)
  • Hair stable isotopes ratio [Between April 2026 to August 2026]: Isotope ratios of δ13C and δ15N in hair sample
  • Fish consumption [Between April and August 2026]: 7 days recall, questionnaire

Other outcomes

  • Climate change perception and mitigation practice [Between April and August 2026]: Climate change and mitigation practice, questionnaire
  • Women empowerment [Between April and August 2026]: Women empowerment will be obtained using women empowerment assessment tool, questionnaire.
  • Dietary pattern, food frequency [Between April 2026 to August 2026]: Dietary pattern by food groups, questionnaire
  • Child omega-3 status [One timepoint between April and August 2026]: If a woman has a child aged 6-59 months, the child is assessed for EPA concentration in blood (% of total fatty acids).
  • Child omega-3 status [One measure between April and August 2026]: If the woman has a child aged 6 months to 5 years, the child is measured for DHA concentration in blood (% of total fatty acid)
  • Micronutrient status, Child [April-August 2026]: If the woman has a child aged 6 months to 5 years, the child is measured for hemoglobin concentration in blood (g/L)
  • Micronutrient status, Child [One sampling point between April and August 2026]: If the woman has a child aged 6 months to 5 years, ferritin concentration in blood (µg/L), will be measured.
  • Micronutrient status, Child [One sampling point between April and August 2026]: If the woman has a child aged 6 months to 5 years, Vitamin D (total 25-hydroxyvitamin D) concentration in blood, nmol/L will be measured.
  • Inflammation status, Child [One sampling point between April and August 2026]: If the woman has a child aged 6 months to 5 years, the child's C-reactive protein concentration in blood (mg/L) will be measured.
  • Inflammation status, Child [One sampling point between April and August 2026]: If the woman has a child aged 6 months to 5 years, alpha-1-acid glycoprotein concentration in blood (g/L) will be measured.
  • Nutritional status, Child [Between April and August 2026]: If the woman has a child aged 6-59 months, the child's length/height (cm) is measured.
  • Nutritional status, Child [April-August 2026]: If the women has a child aged 6-59 months, the child is measured for weight (kg)
  • Nutritional status, Child [April-August 2026]: If the woman has a child aged 6-59 months, the child is measured for MUAC (cm)

+Eligibility

Sex: All, ages: 5 Months to 27 Years, accepts healthy volunteers

Inclusion Criteria:

* Young women aged 22-27 years who previously participated in the 2017 study. See study description.
* If the women has a child age between 6 months to 5 years, the child child is included to be assessed

Exclusion Criteria:

* Participants with serious health conditions that may interfere with study procedures or data collection.

+Locations (1)

FacilityCityCountryStatus
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b)Dhaka, Capital RegionBangladesh

+Publications

  • Ara G, Little DC, Mamun AA, de Roos B, Grieve E, Khanam M, Hasan SMT, Ireen S, Ali SD, Boitchi AB, Dijkhuizen MA, Ahmed T, Roos N. Factors affecting the micronutrient status of adolescent girls living in complex agro-aquatic ecological zones of Bangladesh. Sci Rep. 2023 Apr 24;13(1):6631. doi: 10.1038/s41598-023-33636-8. PMID 37095307
  • Grieve E, Mamun AA, de Roos B, Barman BK, Ara G, Roos N, Pounds A, Sneddon AA, Murray F, Ahmed T, Little DC. Adolescent girls in aquaculture ecozones at risk of nutrient deficiency in Bangladesh development and validation of an integrated metric. BMC Public Health. 2023 Feb 28;23(1):405. doi: 10.1186/s12889-023-15175-z. PMID 36855076