Hypnosis During Mechanical Ventilation Weaning

• Hypnosis (Behavioral): The intervention consists of a standardized hypnosis session delivered by a trained practitioner during the weaning phase from invasive mechanical ventilation in an intensive care unit.

Primary outcomes

• Feasibility of a hypnosis session during weaning from invasive mechanical ventilation. [At the end of the recruitment period]: Number of hypnosis sessions conducted, relative to the number of eligible patients.

Secondary outcomes

• Progression of pain and anxiety during weaning from invasive mechanical ventilation using hypnosis. [During the hypnosis session (Day 1)]: Assessment of pain and anxiety using visual analog scales before and after the hypnosis session.
• Frequency of failed weaning from invasive mechanical ventilation among patients who underwent a hypnosis session. [During ICU stay]: Ventilator weaning failure rate.
• Complications associated with weaning from mechanical ventilation using hypnosis. [During the ICU stay]: Number and types of complications.
• Length of stay in the intensive care unit following weaning from mechanical ventilation using hypnosis. [ICU stay]: Length of stay in the intensive care unit.
• Mortality following weaning from mechanical ventilation using hypnosis. [At day 28]: Death rate
• Patients' experiences [On the day of discharge from the ICU, and no later than Day 28]: Form for patients who received hypnosis during weaning from mechanical ventilation.
• Professionals' perceptions of hypnosis [Throughout the study's enrollment period.]: Form for healthcare professionals who have conducted at least one hypnosis session.

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Patients aged 18 and older
* Patients hospitalized in the intensive care unit and requiring invasive mechanical ventilation for at least 48 hours
* Presence of the prerequisite criteria for ventilator weaning: effective cough, minimal bronchial congestion, patient awake and not agitated, hemodynamic stability (heart rate less than 140 beats per minute, systolic blood pressure between 90 and 160 mmHg without vasopressors), pressure support ventilation, FiO2 < 40% and PEEP ≤ 8 cmH2O, PaO2/FiO2 > 150, pH > 7.35, respiratory rate < 35 per minute
* Patients enrolled in a social security program or eligible for such a program
* Patients who has received complete information about the clinical research protocol and has signed an informed consent form
* Patients who has undergone a preliminary clinical examination appropriate for the clinical research

Exclusion Criteria:

* Contraindication to hypnosis (particularly severe psychotic disorders)
* Non-French-speaking individuals
* Deaf or hard-of-hearing individuals
* State of agitation or acute delirium
* Individuals who have already undergone a spontaneous ventilation test or an attempt at orotracheal extubation during their hospitalization
* Individuals receiving a new anxiolytic or sedative treatment within 2 hours prior to the weaning test
* Individuals with a tracheostomy
* Women of childbearing age who do not have access to effective contraception
* Individuals covered by Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the Public Health Code (pregnant women, women in labor, or breastfeeding women, minors not emancipated, adult subject to a legal protection measure, adult unable to give consent)
* Person deprived of liberty by a judicial or administrative decision, or a person receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1

• Viviane MARTIN, PhD, Study director, The Regional and University Hospital Center of Nancy