Polymeric Nano Calcium Fluoride Varnish, Diode Laser, and Their Combination for Dentin Hypersensitivity

NCT07418788 — Not applicable, Completed, 30 participants, Faculty of Dental Medicine for Girls

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Efficacy of Polymeric Nano Calcium Fluoride Varnish, Diode Laser Individually and in Combination in the Treatment of Dentin Hypersensitivity.

Registry	NCT07418788
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: double, treatment
Enrollment	30 (Actual)
Sponsor	Faculty of Dental Medicine for Girls (Other gov)
Conditions	Dentin Hypersensitivity, Non-carious Cervical Lesions, Gingival Recession Localized Moderate
Interventions	Olinano seal, Diode Laser, Olinano seal and Diode Laser (Other, device)
Dates	start 2025-05-15, primary completion 2025-07-10, completion 2026-07-16, first posted 2026-02-18, last updated 2026-09-18
Locations	1 site in Egypt

-Summary

The aim of the study is to assess the effect of polymeric nano calcium fluoride Varnish (Oli-NANO seal), 976 nm diode laser solely and combination of both therapies in the treatment of dentin hypersensitivity

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+Arms and interventions

Arm	Type	Interventions	Description
Group 1 (OliNano Seal)	Experimental	Other: Olinano seal	OliNano Seal (polymeric nano calcium fluoride containing varnish)
Group 2 (Diode laser)	Active comparator	Device: Diode Laser	Diode laser
Group 3 (OliNano Seal and Diode laser)	Experimental	Other: Olinano seal and Diode Laser	OliNano Seal and Diode laser

Olinano seal (Other): The OliNANO seal is "varnish-like" shield which is based on nanotechnology that allows an optimum adhesion to enamel and dentin, it could be used as an effective desensitizing agent by forming a protective layer that occludes the dentinal tubules which can be effective for a year as mentioned by the manufacturer. Polymeric nano calcium fluoride varnish consists of four main components, silicone polymer, NANO-fluorapatite, nano-calcium fluoride and amine fluoride (Olaflur)
Diode Laser (Device): increase in the metabolic activity of odontoblasts. Thus, obliteration of the dentinal tubules and formation of tertiary dentin.
Olinano seal and Diode Laser (Other): Combined methods have been also evaluated in some previous studies. It showed more effect in reducing Dentin hypersensitivity than using every treatment solely

+Outcome measures

Primary outcomes

Pain severity [Before the treatment (Baseline), after the first session (T1), second session (T2) will be done after a week from the first session, after 3 months (T3), 6 months (T6), 9 months (T9) and 12 months (T12)]: The pain will be assessed using the (VAS) scale. The VAS is a scale that allows the patient to self-assess the pain felt by means of a line in which the patient marks the pain level "no pain" to the "maximum pain". 0: low pain, 1 - 3: moderate pain: 4 - 6, intense pain: 7 - 9, extremely intense pain: 10

+Eligibility

Sex: All, ages: 30 Years to 50 Years, accepts healthy volunteers

Inclusion Criteria:

* Medically free

  * Non-smokers
  * Co-operative patients who will be interested in participating in the study and willing to sign the informed consent.
  * Availability of patients for 1 year

Exclusion Criteria:

* Patients currently using analgesic, anti-inflammatory medications, sedatives, tranquilizers, anticonvulsants, or any other medications that could potentially alter pain perception.

  * Patients undergoing orthodontic treatment.
  * Patients using desensitizing toothpaste
  * Patients receiving dentin hypersensitivity (DH) treatment
  * Pregnant or lactating women
  * Patients have high consumption of sour and acidic food
  * Patients who had undergone professional desensitizing therapy during the previous 3 months.

+Locations (1)

Facility	City	Country	Status
Faculty of Dental medicine for Girls	Cairo	Egypt