Imaging of Electrical Properties by MRI: Investigation of Age-Related Changes

NCT07415759 — Not applicable, Recruiting, 120 participants, Central Hospital, Nancy, France

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Registry	NCT07415759, acronym ELECTRA
Status	Recruiting
Phase	Not applicable
Study type	Interventional; non randomized, parallel, masking: none, other
Enrollment	120 (Estimated)
Sponsor	Central Hospital, Nancy, France (Other)
Conditions	Healthy Subjects
Interventions	Magnetic Resonance Imaging (MRI) examination (Device)
Dates	start 2026-04-04, primary completion 2029-02-02 (estimated), completion 2029-02-02 (estimated), first posted 2026-02-17, last updated 2026-06-12
Locations	2 sites in France

-Summary

The goal of this study is to build a database of personalized EP (Electrical Properties) maps (accounting for age, anatomical location, and tissue complexity), obtained via MRI, to improve electromagnetic safety assessments, especially in the context of MRI. The EP values derived from this study are expected to be more accurate than current literature values, leading to more realistic specific absorption rate (SAR) modeling and improved patient safety. To investigate age-related differences, the study will include three distinct age groups.

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+Arms and interventions

Arm	Type	Interventions
Children between 6 and 12 years old	Experimental	Device: Magnetic Resonance Imaging (MRI) examination
Adults between 20 and 40 years old	Experimental	Device: Magnetic Resonance Imaging (MRI) examination
Adults aged 70 and above	Experimental	Device: Magnetic Resonance Imaging (MRI) examination

Magnetic Resonance Imaging (MRI) examination (Device): MRI examination of the head and neck, and torso for the measurement of electrical properties

+Outcome measures

Primary outcomes

Conductivity in S/m at the head level in subjects aged 6 to 12 years [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the head level in subjects aged 6 to 12 years
Conductivity in S/m at the head level in subjects aged 20 to 40 years [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the head level in subjects aged 20 to 40 years
Conductivity in S/m at the head level in subjects aged 70 and above [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the head level in subjects aged 70 and above
Conductivity in S/m at the neck level in subjects aged 6 to 12 years [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the neck level in subjects aged 6 to 12 years
Conductivity in S/m at the neck level in subjects aged 20 to 40 years [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the neck level in subjects aged 20 to 40 years
Conductivity in S/m at the neck level in subjects aged 70 and above [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the neck level in subjects aged 70 and above
Conductivity in S/m at the torso level in subjects aged 6 to 12 years [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the torso level in subjects aged 6 to 12 years
Conductivity in S/m at the torso level in subjects aged 20 to 40 years [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the torso level in subjects aged 20 to 40 years
Conductivity in S/m at the torso level in subjects aged 70 and above [Baseline (J0)]: Measurement of conductivity (in Siemens per meter, S/m) at the torso level in subjects aged 70 and above

+Eligibility

Sex: All, ages: 6 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Person aged between 6 and 12, 20 and 40 years or aged 70 years and above
* Person affiliated with a social security scheme or beneficiary of such a scheme
* Person, or parent/legal guardian in the case of minors, who has received full information about the organization of the study and has signed the informed consent form

Exclusion Criteria:

* Contraindication to undergoing an MRI examination or the presence of an MRI-incompatible medical device
* Person presenting a pathology or tissue damage in the examined areas that may affect the measured MRI parameters
* Pregnant woman, woman in labor, or breastfeeding mother
* Person deprived of liberty by judicial or administrative decision, or persons undergoing psychiatric care

+Locations (2)

Facility	City	Country	Status
CHRU Nancy	Vandœuvre-lès-Nancy, CHRU de Nancy	France	Recruiting
Institut de Physique Biologique	Strasbourg	France	Recruiting