Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors

NCT07413640 — Recruiting, 90 participants, Central Hospital, Nancy, France

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Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors : a Retrospective Study

Registry	NCT07413640, acronym MICRO-VAR
Status	Recruiting
Study type	Observational
Enrollment	90 (Estimated)
Sponsor	Central Hospital, Nancy, France (Other)
Conditions	Liver Neoplasm
Dates	start 2026-02-02, primary completion 2026-07-31, completion 2026-12-31 (estimated), first posted 2026-02-17, last updated 2026-10-21
Locations	1 site in France

-Summary

Microwave ablation is a minimally invasive technique whose planning relies on manufacturer tables derived from ex vivo models that do not account for patient or tumor-specific factors. In clinical practice, the actual ablation volume often differs from the planned volume due to liver characteristics, vascular proximity, and tumor biology.

This study aims to assess the variability between ablation small axis during percutaneous microwave ablation of liver lesions. The influence of patient-related (fibrosis, steatosis, portal flow) and tumor-related factors (location, histology, prior treatment) will be evaluated. Small axis and volume will be compared with volumes measured on immediate post-procedural CT and on CT/MRI at 6-12 weeks, accounting for expected tissue shrinkage.

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+Outcome measures

Primary outcomes

Small final ablation axis measured on the post-procedure imaging modality considered to be the most reliable. [12 weeks]: The final short axis will preferably be measured (in mm) on MRI at 6-12 weeks. If inter-patient variability in volume shrinkage exceeds 5%, the modality with the lowest relative variability (usually the immediate CT scan) will be used as the reference for estimating the final volume.

+Eligibility

Sex: All, ages: 18 Years to 100 Years

Inclusion Criteria:

* Adult patients
* Treated with percutaneous hepatic microwave ablation under CT or ultrasound guidance
* Adult treated for one or more liver lesions
* Patients with available follow-up imaging

Exclusion Criteria:

* Two treatment cycles on the same lesion during the same session.
* Reoperation on the same lesion.
* Planned volume not available (no manufacturer data, not specified in the surgical report).
* No control imaging injected between 1 and 4 months post-procedure.
* Final ablation volume not measurable (e.g., artifacts, no injection on MRI).
* No definitive diagnosis of the nature of the tumor on imaging and no histology available.

+Locations (1)

Facility	City	Country	Status
CHRU Nancy	Vandœuvre-lès-Nancy	France	Recruiting