Mechanisms of Fecal Incontinence in Wolfram Syndrome

NCT07313085 — Not yet recruiting, 20 participants, Hôpital Necker-Enfants Malades
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Physiopathogenic Mechanisms of Fecal Incontinence in Wolfram Syndrome

RegistryNCT07313085
StatusNot yet recruiting
Study typeObservational
Enrollment20 (Estimated)
SponsorHôpital Necker-Enfants Malades (Other)
ConditionsWolfram Syndrome, Fecal Incontinence
InterventionsRetrospective case-control analysis (Other)
Datesstart 2025-12-20 (estimated), primary completion 2026-01-01 (estimated), completion 2026-02-01 (estimated), first posted 2025-12-31, last updated 2025-12-31
Locations1 site in France

Related Papers Related Patents Related Grants Related Experts
All trials for Wolfram Syndrome All trials for Fecal Incontinence All trials of Retrospective case-control analysis

-Summary

In order to clarify the mechanism of fecal incontinence in in Wolfram syndrome and to characterize its risk factors, the examiner will reviewed the files of patients followed in a Reference Center for Rare Diseases in Ophthalmology.

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+Arms and interventions

ArmTypeInterventionsDescription
Wolfram syndrome patients with fecal incontienceOther: Retrospective case-control analysiswolfram syndrome patients without fecal incontinence
Wolfram syndrome patients without fecal incontienceOther: Retrospective case-control analysis
  • Retrospective case-control analysis (Other): retrospective analysis of data

+Outcome measures

Primary outcomes

  • Urinary disorders [The date at the baseline]: number of patients with urinary disorder in each group according to the group

Secondary outcomes

  • sleep apnea [The date the data will be analyzed at the baseline]: number of patients with sleep apnea in each group according to the group
  • frequence of swallowing disroder [The data will be analyzed at baseline]: number of patients with swallowing disorders in each group according to the group
  • frequence of diabetes insipidus [The data will be analyzed at baseline]: number of patients with diabetes insipidus in each group according to the group
  • mutation type [The data will be analyzed at baseline]: report of mutations of WFS1 in each group

+Eligibility

Sex: All

Inclusion Criteria:

* Wolfram syndrome

Exclusion Criteria:

* no information concerning fecal incontinence in data records

+Locations (1)

FacilityCityCountryStatus
HEGPParisFrance