3D Liver Volumetry

NCT07297615 — Not applicable, Not yet recruiting, 25 participants, Medical University of Graz

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Accuracy of Individualized 3D Reconstruction in Predicting Liver Resection Volume: A Prospective Study

Registry	NCT07297615
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, other
Enrollment	25 (Estimated)
Sponsor	Medical University of Graz (Other)
Conditions	Liver Surgery, Liver Cancer, Surgical Planning, Liver, Volumetric Analysis, 3D-reconstruction
Interventions	3d reconstruction (Diagnostic test)
Dates	start 2026-04-01 (estimated), primary completion 2028-03-31 (estimated), completion 2028-09-30 (estimated), first posted 2025-12-22, last updated 2026-02-17
Locations	1 site in Austria

-Summary

The study aims to improve preoperative evaluation of liver resection volume in patients undergoing major hepatectomies. Accurate prediction of the planned resection and the future liver remnant (FLR) is critical to minimize the risk of postoperative liver failure, which is associated with increased morbidity and mortality. Conventional imaging-based volumetry may have limited accuracy. This study investigates the use of individualized 3D liver models combined to enhance visualization and volumetric analysis of liver anatomy and resection boundaries.

Patients are recruited in the liver outpatient clinic and, upon consent, preoperative 3D models are created using Medics 3D. During surgery, the planned resection is guided by the individualized 3D models. Postoperatively, the resected specimen undergoes CT-based volumetry to compare the predicted resection volume from the 3D model with the actual volume. Routine postoperative follow-up is conducted. The study aims to optimize surgical planning, enhance the accuracy of future liver remnant prediction.

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+Arms and interventions

Arm	Type	Interventions	Description
Volumetry through 3D reconstruction	Experimental	Diagnostic Test: 3d reconstruction	Preoperative liver volumetry using individualized 3D reconstructions to guide major hepatectomy, optimize resection planning, and improve prediction of the future liver remnant.

3d reconstruction (Diagnostic test): Preoperatively, every patient in this study will undergo an individualized 3D reconstruction of their liver to perform accurate volumetry.

+Outcome measures

Primary outcomes

Assessment of the preoperative volumetry of the liver portion planned for resection using a 3D model and comparison with the postoperative resection specimen volume. [Approximately 2-3 weeks are required between preoperative volumetry and postoperative volumetry comparison.]

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Adult patients (≥18 years) undergoing open or minimally invasive major liver resection at the Clinical Division of General, Visceral and Transplant Surgery who provide written informed consent prior to participation will be included.

Exclusion Criteria:

* Patients unable to provide informed consent will be excluded.
* Minor resections.
* Contraindications to MRI.

+Locations (1)

Facility	City	Country	Status
Medical University of Graz - Department of Surgery, Division of General, Visceral and Transplantationsurgery	Graz	Austria