Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience

NCT07291882 — Completed, 400 participants, Minia University

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RegistryNCT07291882
StatusCompleted
Study typeObservational
Enrollment400 (Actual)
SponsorMinia University (Other)
ConditionsAppendicitis, Surgery
InterventionsAppendectomy (Procedure)
Datesstart 2024-09-01, primary completion 2024-09-10, completion 2025-08-20, first posted 2025-12-18, last updated 2025-12-29
Locations1 site in Egypt

Related Papers Related Patents Related Grants Related Experts
All trials for Appendicitis, Surgery All trials of Appendectomy

-Summary

Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low. Because testing is rapid, inexpensive, and universally available, integration into local diagnostic pathways is feasible.

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+Arms and interventions

ArmTypeInterventionsDescription
Simple appendicitis ( group A)Procedure: AppendectomyPatients where no perforation, gangrene, or other complications were found during surgery.
Complicated appendicitis (group B)Procedure: Appendectomy• Complicated appendicitis group (B): Patients who presented with perforation or gangrene, confirmed via operative findings and histopathological examination. Total bilirubin levels was measured preoperatively as part of the routine laboratory workup.
  • Appendectomy (Procedure): Total bilirubin levels was measured preoperatively as part of the routine laboratory workup. Appendectomy done for all patients followed by histopathological evaluation of the excised appendix.

+Outcome measures

Primary outcomes

  • measurement of serum total bilirubin in each case of appendicitis to clarify the relationship between serum hyperbilirubinemia and complicated appendicitis [between September 2024 and August 2025]

+Eligibility

Sex: All

Inclusion Criteria:

* All patients presented with right iliac fossa pain diagnosed clinically as acute appendicitis and had undergone appendectomy

Exclusion Criteria:

* patients with past history of jaundice
* patients with history of hyperbilirubinemia hemolytic disease
* positive hepatitis viruses
* cholelithiasis
* acquired or congenital biliary disease
* cancer of the hepatobiliary system

+Locations (1)

FacilityCityCountryStatus
Minia universityMinyaEgypt