Test Serum Clinical Study

• HA injection (Other): Using vacuum negative pressure technology, hyaluronic acid and other moisturizing nutrients are directly injected into the deep skin, effectively improving dermal dehydration and dryness from the muscle base, so that the skin can quickly replenish water.
• Facial serum application (Other): Dosage on face: About 0.5g/face for serum.

Primary outcomes

• Skin Hydration Level via Corneometer CM825 [Measurements are taken at Baseline (T0) , 10 minutes post-application (for Group 1 only), 1 hour post-application (T1h) , Day 1 (T1D) , Day 3 (T3D) , Day 7 (T7D) , Day 14 (T14D) , Day 21 (T21D) , and Day 28 (T28D) .]
• Skin Barrier Function via Vapometer® (TEWL Measurement) [Measurements are taken at Baseline (T0) , 10 minutes post-application (for Group 1 only), 1 hour post-application (T1h) , Day 1 (T1D) , Day 3 (T3D) , Day 7 (T7D) , Day 14 (T14D) , Day 21 (T21D) , and Day 28 (T28D) .]
• Skin Elasticity via Cutometer® Dual MPA 580 [Measurements are taken at Baseline (T0) , 10 minutes post-application (for Group 1 only), 1 hour post-application (T1h) , Day 1 (T1D) , Day 3 (T3D) , Day 7 (T7D) , Day 14 (T14D) , Day 21 (T21D) , and Day 28 (T28D) .]
• Facial Skin Redness and Wrinkle Mapping via VISIA-7 Imaging [Images are captured at Baseline (T0) , 10 minutes post-application (for Group 1 only), 1 hour post-application (T1h) , Day 1 (T1D) , Day 3 (T3D) , Day 7 (T7D) , Day 14 (T14D) , Day 21 (T21D) , and Da]
• 3D Topographical Analysis of Wrinkles and Pores via Antera 3D [Measurements are taken at Baseline (T0) , 10 minutes post-application (for Group 1 only), 1 hour post-application (T1h) , Day 1 (T1D) , Day 3 (T3D) , Day 7 (T7D) , Day 14 (T14D) , Day 21 (T21D) , and Day 28 (T28D) .]
• Subjective Skin Tolerance and Sensation via Self-Assessment Questionnaire [Questionnaires are administered at Baseline (T0) , 10 minutes post-application (for Group 1 only), 1 hour post-application (T1h) , Day 1 (T1D) , Day 3 (T3D) , Day 7 (T7D) , Day 14 (T14D) , Day 21 (T21D) ,]

Sex: Female, ages: 25 Years to 40 Years, accepts healthy volunteers

Inclusion Criteria:

1. Chinese female with 25-40 years old.
2. All skin types by subjects' self-perceived.
3. Willing to perform HA injection.
4. Did not perform any of the beauty procedure projects in the past 6 months.
5. Lack of hydration, radiance, brightness, smoothness, firmness and elasticity by self-claimed.
6. Presenting with corresponding severity for the attribute evaluated by Dermatologist included:

   * Radiance, smoothness, elasticity, cheek plumpness and firmness: 3≤grade≤6.
   * Global fine lines: 3≤grade.
   * Underneath eye wrinkles: 2≤grade≤5.
   * Forehead wrinkles: 1<grade≤4.
   * Glabella wrinkles: 1<grade.
7. All accept not to use any cosmetics, skincare products, beauty equipment, all topical medications and cleansing products on face at visit days.
8. Did not participate any clinical test or cosmetic product test on skin within 1 months.
9. No disagreement of dermatologist because of other reasons that exclude the participation of the volunteer.
10. In general, good health at the time of the study.
11. Willing and able to participate as evidenced by signing of informed consent \& photo release form.
12. Must be willing to comply with all study protocol requirements.

Exclusion Criteria:

1. Pregnant or breast-feeding woman or woman planning pregnancy during the study.
2. Subject deprived of rights by a court or administrative order.
3. Major subject to a guardianship order.
4. Subject residing in a health or social care establishment.
5. Patient in an emergency setting.
6. Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
7. Subject presenting a stable or progressive serious disease (per investigator's assessment).
8. Immuno-compromised subject.
9. Subject with history of allergy to cosmetic or personal care products or ingredients.
10. Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
11. Subject with history of sunlight sensitivity or allergies.
12. Subject regularly practicing aquatic or nautical sports.
13. Subject regularly attending a sauna.
14. Subject with physical highly sensitive constitution.
15. Subject with cardiovascular or circulatory history.
16. Subject with a history of skin cancer or malignant melanoma.
17. Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.