Effect of Mechanical Load Magnitude on Reflex Latency Induced by Whole-Body Vibration: A Latency-Based Evaluation of Bone Myoregulation Reflex and Tonic Vibration Reflex
| Registry | NCT07170709, acronym WBV-BMR |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, crossover, masking: none, basic science |
| Enrollment | 30 (Actual) |
| Sponsor | Selim Sezikli (Other gov) |
| Conditions | Whole-body Vibration, Healthy Volunteers (HV), Muscle Contraction, Postural Balance, Electromyography |
| Interventions | Whole-Body Vibration (Device) |
| Dates | start 2025-09-02, primary completion 2025-09-20, completion 2025-09-24, first posted 2025-09-12, last updated 2026-10-07 |
| Locations | 1 site in Turkey (Türkiye) |
Related Papers Related Patents Related Grants Related Experts
All trials for Whole-body Vibration All trials for Healthy Volunteers (HV) All trials of Whole-Body Vibration
This study aims to investigate how the magnitude of mechanical loading affects reflex latency patterns induced by whole-body vibration (WBV). WBV can trigger two types of reflexes: the tonic vibration reflex (TVR) and the bone myoregulation reflex (BMR), which may be influenced by load-bearing condition. The study will include healthy adult volunteers aged 20-50 years. Reflex responses will be recorded from the soleus muscle using surface EMG during both WBV. Different conditions of mechanical loading (i.e., standing on one foot, both feet) and vibration frequencies (30-36 Hz) will be tested. The main outcome will be the latency of the reflex responses, which will help distinguish between TVR and BMR activation. The goal is to better understand how mechanical load modifies reflex response timing and to characterize the underlying afferent pathways. This knowledge may contribute to optimizing vibration-based rehabilitation strategies.
This study investigates how the magnitude of mechanical loading alters reflex latency patterns during whole-body vibration (WBV), focusing specifically on the tonic vibration reflex (TVR) and the bone myoregulation reflex (BMR). Experimental data suggest that WBV may activate different reflex mechanisms depending on the level of postural loading, frequency, and amplitude of the vibration. Previous studies have shown that low-amplitude WBV tends to activate TVR under voluntary contraction, while higher mechanical loads and neutral standing posture are more likely to induce BMR.
Surface electromyography (sEMG) recordings will be obtained from the soleus muscle during vibration stimuli applied at different frequencies (30, 32, 34, and 36 Hz). Recordings will be taken under multiple loading conditions: standing on both feet, standing on one foot. Reflex latency will be calculated using cumulative averaging techniques, and data will be analyzed offline using Spike2 software.
Findings from this study may contribute to a deeper understanding of reflex integration during vibratory stimulation and inform future neurorehabilitation protocols that utilize WBV as a therapeutic modality.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Low load first | Other | Device: Whole-Body Vibration | Participants first underwent low-load whole-body vibration (bipedal stance, 1.2 mm peak-to-peak platform displacement), followed by high-load whole-body vibration (unipedal stance, 2.2 mm peak-to-peak displacement). Within each condition, 10-s vibration blocks were delivered at 30, 32, 34 and 36 Hz in randomized order. Participants stood in quiet upright stance with the hands resting lightly on a fixed bar. |
| High load first | Other | Device: Whole-Body Vibration | Participants first underwent high-load whole-body vibration (unipedal stance, 2.2 mm peak-to-peak platform displacement), followed by low-load whole-body vibration (bipedal stance, 1.2 mm peak-to-peak displacement). Within each condition, 10-s vibration blocks were delivered at 30, 32, 34 and 36 Hz in randomized order. Participants stood in quiet upright stance with the hands resting lightly on a fixed bar. |
Sex: All, ages: 18 Years to 45 Years, accepts healthy volunteers
Inclusion Criteria: * Aged between 18 and 40 years * Healthy adult volunteers with no known neurological or musculoskeletal disorders * Able to provide informed consent * Willing to comply with the procedures of the study, including EMG and vibration exposure Exclusion Criteria: * History of any neurological condition (e.g., peripheral neuropathy, spinal cord injury, stroke) * Musculoskeletal injury or surgery involving the lower extremities * Use of medications affecting neuromuscular function * Pregnancy * Presence of implanted electronic devices (e.g., pacemaker) * Known intolerance to vibration exposure
| Facility | City | Country | Status |
|---|---|---|---|
| Istanbul Physical Medicine and Rehabilitation Training and Research Hospital | Istanbul, Istanbul | Turkey (Türkiye) |