Adaptive Cell Phone Support (ACPS)

NCT07064824 — Not applicable, Not yet recruiting, 96 participants, Children's Hospital Los Angeles

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Adaptive Cell Phone Support to Promote Medication Adherence Among Adolescents and Young Adults With Chronic Health Conditions

Registry	NCT07064824, acronym ACPS
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; randomized, sequential, masking: none, supportive care
Enrollment	96 (Estimated)
Sponsor	Children's Hospital Los Angeles (Other)
Conditions	Medication Adherence
Interventions	Adaptive Cell Phone Support, Computer-Delivered Cell Phone Support, Automated Text Reminders (Behavioral)
Dates	start 2027-08-01 (estimated), primary completion 2029-07-30 (estimated), completion 2030-07-30 (estimated), first posted 2025-07-15, last updated 2025-07-30
Locations	1 site in United States

-Summary

The goal of this pilot clinical trial is to test a mobile health intervention for promoting medication adherence in a population of adolescents and young adults with chronic health conditions. The main question it aims to answer is:

-Is an adaptive intervention (personalizing the intensity of support based on patients' needs) efficacious for promoting medication adherence Researchers will compare the adaptive intervention to automated text message reminders see if the adaptive intervention shows stronger positive effects on medication adherence.

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+Detailed description

Plan to enroll 96 participants in this study, which is a sequential randomized trial.

+Arms and interventions

Arm	Type	Interventions	Description
Adaptive Cell Phone Support	Experimental	Behavioral: Adaptive Cell Phone Support; Behavioral: Computer-Delivered Cell Phone Support	Computer-delivered cell phone support (reminders, problem-solving, referrals to resources) and responsive human coaching (phone calls, test messages, in-app messaging) to improve medication adherence.
Computer-Delivered Cell Phone Support	Experimental	Behavioral: Computer-Delivered Cell Phone Support	Computer-delivered cell phone support (reminders, problem-solving, referrals to resources)
Automated Text Reminders	Active comparator	Behavioral: Automated Text Reminders	Scheduled one-way text automated message reminders to take medication

Adaptive Cell Phone Support (Behavioral): Mobile health adherence promotion based on the supportive accountability model
Computer-Delivered Cell Phone Support (Behavioral): Mobile health adherence promotion based on the supportive accountability model
Automated Text Reminders (Behavioral): Scheduled text reminder to take medication

+Outcome measures

Primary outcomes

Mean scores on the Mobile Health App Usability Questionnaire [Baseline to 12 weeks]: Higher scores indicate greater ease with which users can use technology to achieve a particular goal; the minimum value of this questionnaire is 1 and the maximum value is 7.
Total scores on the theoretical framework of acceptability questionnaire [Baseline to 12 weeks]: Higher scores indicate a greater "extent to which people delivering or receiving a healthcare intervention consider it to be appropriate, based on anticipated or experienced cognitive and emotional responses to the intervention"; the minimum value of this questionnaire is 7 and the maximum value is 35.
Total scores on the Visual Analogue Scale [Baseline to 12 weeks]: Percentage of doses taken our of 100%; higher numbers indicate greater medication adherence. This scale presents participants with a line, marked 0 on the left and 100 on the right, and participants can drag a marker to the place on the line that best visually indicated their adherence.
Total scores on Rollnick's Readiness Ruler [Baseline to 12 weeks]: Higher scores on this measure indicate more motivation to take medication as prescribed; the minimum value of this questionnaire is 0 and the maximum value is 10.
Total Transition Readiness scores on the Successful Transition to Adulthood with Therapeutic = Rx Questionnaire [Baseline to 12 weeks]: Higher scores on extent to which patients are prepared to manage their health condition as adults, outside of the pediatric system; ; the minimum value of this questionnaire is 0 and the maximum value is 90.

+Eligibility

Sex: All, ages: 15 Years to 20 Years

Inclusion Criteria:

* Children's Hospital Los Angeles patient
* between 15-20 years old
* taking at least one oral medication per day for a chronic health condition
* English speaking
* demonstrating sufficient cognitive capacity to engage in the assent/consent process and study procedures

There is no exclusion criteria.

+Locations (1)

Facility	City	Country	Status
Children Hospital Los Angeles	Los Angeles, California	United States

+Investigators

Caitlin Sayegh, PhD, Principal investigator, Children's Hospital Los Angeles