A Retrospective Comparison Of The Effects Of Low-Flow And High-Flow Anesthesia On Hemodynamics, Neutrophil-To-Lymphocyte Ratio, And Postoperative Outcomes In Tympanoplasty And Myringoplasty Surgeries
| Registry | NCT07064642, acronym ANFLUX |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 50 (Actual) |
| Sponsor | Eda KAZANÇ ÖZDEN (Other) |
| Conditions | Tympanoplasty, Myringoplasty, Neutrophil-to-Lymphocyte Ratio, Low-flow Anesthesia, High-flow Anesthesia |
| Dates | start 2023-07-20, primary completion 2023-08-20, completion 2023-09-20, first posted 2025-07-15, last updated 2025-07-17 |
| Locations | 1 site in Turkey (Türkiye) |
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All trials for Tympanoplasty All trials for Myringoplasty
This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between \[September 1, 2022\] and \[April 1, 2023\]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.
This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Low-flow anesthesia group | Low-flow anesthesia group 0.75 L/min : Patients who underwent tympanoplasty or myringoplasty under low-flow anesthesia technique. The anesthetic gas flow rate was maintained at low levels throughout the procedure to evaluate its effects on systemic inflammation and hemodynamics. | ||
| High-flow anesthesia group | High-flow anesthesia group 3 L/min : Patients who underwent tympanoplasty or myringoplasty under high-flow anesthesia technique. The anesthetic gas flow rate was maintained at high levels throughout the procedure to compare its impact on inflammatory response and postoperative outcomes. |
Sex: All, ages: 18 Years to 75 Years
Inclusion Criteria: * Adults aged between 18 and 75 years * American Society of Anesthesiologists (ASA) physical status classification I to III * Body Mass Index (BMI) between 18.5 and 29.9 kg/m² Exclusion Criteria: * Age below 18 or above 75 years * Incomplete or missing clinical data * BMI less than 18.5 kg/m² or greater than 29.9 kg/m² * Presence of neurological disorders * History of renal or hepatic failure
| Facility | City | Country | Status |
|---|---|---|---|
| Karadeniz Technical University Faculty of Medicine Hospital | Trabzon, Trabzon | Turkey (Türkiye) |