Efficacy of Oral Tofacitinib in Combination of Narrow Band UVB in Treatment of Vitiligo

NCT07044141 — Phase 1, Active not recruiting, 20 participants, Lahore General Hospital

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Efficacy of Oral Tofacitinib in Combination With Narrow Band UVB in the Treatment of Vitiligo

Registry	NCT07044141, acronym NB-UVB
Status	Active not recruiting
Phase	Phase 1
Study type	Interventional; randomized, parallel, masking: none, treatment
Enrollment	20 (Estimated)
Sponsor	Lahore General Hospital (Other gov)
Conditions	Vitiligo
Interventions	Azathioprine, Tofacitinib (Drug)
Dates	start 2025-03-01, primary completion 2025-09-30 (estimated), completion 2025-09-30 (estimated), first posted 2025-06-29, last updated 2025-06-29
Locations	1 site in Pakistan

-Summary

20 patients will be enrolled. All were given narrowband UVB . 10 wil be give oral azathriopfine . 10 will be given tofacitinib

Expand all sections · Collapse all

+Detailed description

Total 20 patients will be enrolled. All were given narrowband UVB . 10 wil be give oral azathriopfine 50mg twice daily. 10 will be given tofacitinib 5mg twice daily. For 6 months

+Arms and interventions

Arm	Type	Interventions	Description
Group A	Active comparator	Drug: Azathioprine	Azathioprine is an immunomodulator used in treatment of vitiligo
Group B	Active comparator	Drug: Tofacitinib	Tofacitinib It is a Janu kinase pathway inhibitor

Azathioprine (Drug): azathioprine 50mg twice daily will be given
Tofacitinib (Drug): It is a janus kinase inhibitor

+Outcome measures

Primary outcomes

VASI improvement upto 50% [6 months]: Study will be considered efficacious if 50% improvement in VASI from baseline is seen by end of 6 months of study

+Eligibility

Sex: All, ages: 18 Years to 60 Years

Inclusion Criteria:

* patient of vitiligo with any VASI both genders 18 to 60yrs

Exclusion Criteria:

* pregnancy/lactation Hyerlipidrmia Patient on immunemodulator Histry pf tuberculosis Immunocompromised patients

+Locations (1)

Facility	City	Country	Status
Lahore general.hospital	Lahore, Punjab Province	Pakistan