Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study

NCT07041905 — Not applicable, Recruiting, 15 participants, Cukurova University

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Registry	NCT07041905
Status	Recruiting
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: double, treatment
Enrollment	15 (Estimated)
Sponsor	Cukurova University (Other)
Conditions	Pulp Exposure, Dental, Deep Dental Caries
Interventions	Total Caries Removal, Selective Caries Removal (Procedure)
Dates	start 2025-07-01, primary completion 2026-02-01, completion 2026-08-01 (estimated), first posted 2025-06-27, last updated 2026-03-30
Locations	1 site in Turkey (Türkiye)

-Summary

The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.

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+Arms and interventions

Arm	Type	Interventions	Description
Arm 1	Active comparator	Procedure: Total Caries Removal	Complete caries excavation
Arm 2	Experimental	Procedure: Selective Caries Removal	Partial caries excavation

Total Caries Removal (Procedure): Arm 1: "Total caries removal (complete excavation to hard dentin)"
Selective Caries Removal (Procedure): Partial removal leaving affected dentin near pulp.

+Outcome measures

Primary outcomes

Early postoperative pain intensity (VAS) after total vs. selective excavation [first week]: The patient will be asked to rate his/her pain on day 1, 3 and 7 according to VAS
dentin bridge formation [twelve months]: no dentin bridge formation is expected in selective caries cleaning, while dentin bridge formation will be observed radiologically in total cleaning
pulp survival at twelve months [twelve months]: The pulp is expected to remain vital, with no percussion tenderness and no spontaneous pain

+Eligibility

Sex: All, ages: 15 Years to 55 Years

Inclusion Criteria:

* Patients aged ≥15 years with bilateral deep carious mature permanent teeth.
* Positive vitality test (cold sensitivity).
* No spontaneous pain or periapical radiolucency.
* Willingness to attend 6- and 12-month follow-ups

Exclusion Criteria:

* Uncontrolled systemic diseases Pregnancy or allergy to dental materials used Teeth with irreversible pulpitis (spontaneous pain, necrosis) Non-restorable teeth (fractures, extensive decay)

+Locations (1)

Facility	City	Country	Status
Cukurova University	Adana	Turkey (Türkiye)	Recruiting