Neural Mobilization Exercises on Pain and Central Sensitization

NCT07027059 — Not applicable, Suspended, 30 participants, Izmir Katip Celebi University

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The Effect of Neural Mobilization Exercises on Pain and Central Sensitization in Individuals With Lateral Epicondylitis: A Randomized Controlled Trial

Registry	NCT07027059
Status	Suspended - The study was halted due to time constraints
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: double, treatment
Enrollment	30 (Estimated)
Sponsor	Izmir Katip Celebi University (Other)
Conditions	Lateral Epicondylitis
Interventions	median nerve mobilization, routine exercises for lateral epicondylisits (Behavioral)
Dates	start 2026-02-01, primary completion 2027-02-01 (estimated), completion 2027-03-01 (estimated), first posted 2025-06-18, last updated 2026-02-23
Locations	1 site in Turkey (Türkiye)

-Summary

This study aims to investigate the effects of neural mobilization exercises on central sensitization and pain characteristics in individuals with lateral epicondylitis. Enrolled participants will be randomly assigned to two groups. One group will receive routine exercises and ESWT treatment, while the other group will receive neural mobilization exercises in addition to routine exercises and ESWT treatment.

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+Detailed description

Median nerve mobilizations will be implemented as the neural mobilization exercises. All groups will receive two sessions per week and complete the process in four weeks; therefore, they will have received a total of eight sessions by the end of the study. Routine exercises and median nerve mobilizations will be implemented in every session (twice a week), while ESWT will be implemented once a week.

Median nerve mobilizations will be administered in 5 sets, each consisting of 10 repetitions per session.

Before and after the sessions, subjective factors related to pain will be assessed using the Central Sensitization Scale and the Pain Catastrophizing Scale, as well as pressure pain threshold measurements.

+Arms and interventions

Arm	Type	Interventions	Description
mobilization	Experimental	Behavioral: median nerve mobilization; Behavioral: routine exercises for lateral epicondylisits	participants will receive additional median nerve mobilizations
control	Active comparator	Behavioral: routine exercises for lateral epicondylisits	participants will receive routine exercises

median nerve mobilization (Behavioral): An exercise to increase median nerve mobility by flexing and extending fingers, wrist, elbow, shoulder, and neck
routine exercises for lateral epicondylisits (Behavioral): eccentric strengthening exercises

+Outcome measures

Primary outcomes

Central Sensitization [baseline and after the 8 sessions (4th week)]: pressure pain threshold

Secondary outcomes

Central Sensitization [baseline and after the 8 sessions (4th week)]: Central Sensitization scale
Pain Catastrophizing [baseline and after the 8 sessions (4th week)]: Pain Catastrophizing scale

+Eligibility

Sex: All, ages: 18 Years to 65 Years

Inclusion Criteria:

* Clinical diagnosis of lateral epicondylitis
* 18-65 years old

Exclusion Criteria:

Any other pathology, disease, condition, pain, surgery on the elbow, wrist, fingers, shoulder, or neck in the last year

+Locations (1)

Facility	City	Country	Status
Izmir Katip Celebi University	Izmir	Turkey (Türkiye)

+Publications

Coombes BK, Bisset L, Vicenzino B. Management of Lateral Elbow Tendinopathy: One Size Does Not Fit All. J Orthop Sports Phys Ther. 2015 Nov;45(11):938-49. doi: 10.2519/jospt.2015.5841. Epub 2015 Sep 17. PMID 26381484

+Investigators

kevser sevik kacmaz, pt, phd, Principal investigator, Izmir Katip Celebi University