Comparison of Efficacy of Topical Adaplene Gel Versus Crythotherapy in Recurrent Plantar Warts

NCT07016360 — Phase 4, Recruiting, 98 participants, Khyber Teaching Hospital

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Comparison of Efficacy of Topical Adapalene Gel Versus Cryotherapy in Recurrent Plantar Warts

Registry	NCT07016360
Status	Recruiting
Phase	Phase 4
Study type	Interventional; randomized, parallel, masking: none, treatment
Enrollment	98 (Estimated)
Sponsor	Khyber Teaching Hospital (Other)
Conditions	Viral Warts
Interventions	Topical Adapalene Gel 0.1%, Topical Liquid Nitrogen application (Drug, procedure)
Dates	start 2025-09-15, primary completion 2026-02-15, completion 2026-09-15 (estimated), first posted 2025-06-11, last updated 2026-04-29
Locations	1 site in Pakistan

-Summary

This is a comparative study between two treatment options for skin viral infection.

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+Detailed description

This is a comparative study between two treatment for viral infection in epidermal layer of skin that proliferates slowly forming thick, growths. This study will compare and evaluate the differences in efficacy between topical liquid nitrogen and topical retinoids.

+Arms and interventions

Arm	Type	Interventions	Description
A	Experimental	Drug: Topical Adapalene Gel 0.1%	Treated with Topical adapalene gel 0.1%
B	Experimental	Procedure: Topical Liquid Nitrogen application	Treated with liquid nitrogen over affected parts

Topical Adapalene Gel 0.1% (Drug): Topical adapalene is a retinoid that helps in epidermal changes. Cryotherapy is a liquid nitrogen applied to affected parts for 6 months
Topical Liquid Nitrogen application (Procedure): Liquid Nitrogen will be applied to affected parts.

+Outcome measures

Primary outcomes

Efficacy of Treatment [06 months]: It will be defined through visual inspection by observing the complete clearance of the warts after 8 weeks administration of the treatment in both groups

+Eligibility

Sex: All, ages: 18 Years to 60 Years

Inclusion Criteria:

\-

Patients age limit 18-60 Years Patients with either gender (Male/Female) Patients with recurrent plantar warts

Exclusion Criteria:

* Pregnancy/lactation. Pt on topical or systemic therapy in last 6 months. On immunosuppressants. > 5 lesions. Pts with local secondary infections.

+Locations (1)

Facility	City	Country	Status
Khyber Teaching Hospital	Peshawar, Khyber Pakhtunkhwa	Pakistan	Recruiting

+Investigators

Saba Naz, MBBS, Principal investigator, Khyber Teaching Hospital

My Notes

Public

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