What Lies Beneath the Stone? Metabolic Insights From Composition-based Analysis of Kidney Stones
| Registry | NCT06992206, acronym Kidney stone |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 506 (Actual) |
| Sponsor | Hisar Intercontinental Hospital (Other) |
| Conditions | Urolithiasis, Calcium Oxalate |
| Interventions | Metabolik taş analizi ile retrospektif gözlem (Other) |
| Dates | start 2010-01-01, primary completion 2024-12-31, completion 2024-12-31, first posted 2025-05-28, last updated 2025-05-28 |
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All trials for Urolithiasis, Calcium Oxalate All trials of Metabolik taş analizi ile retrospektif gözlem
This retrospective observational study investigates the metabolic abnormalities associated with different types of kidney stones by analyzing their composition. The study includes adult patients diagnosed with urolithiasis, whose stone samples were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Clinical, biochemical, and 24-hour urine metabolic parameters were compared between first-time and recurrent stone formers, and among subtypes of calcium oxalate stones (monohydrate vs. dihydrate). The goal is to identify metabolic risk factors that contribute to stone formation and recurrence, and to provide insights for individualized prevention strategies.
This retrospective study aims to evaluate the metabolic characteristics of patients with urolithiasis based on kidney stone composition. Data were collected from patients treated for kidney stones between January 2010 and December 2024 at a tertiary urology center. Stone analysis was performed using FTIR spectroscopy, classifying stones into subtypes including calcium oxalate monohydrate (COM), calcium oxalate dihydrate (COD), uric acid, and mixed types.
Serum levels of calcium, phosphorus, uric acid, creatinine, and parathyroid hormone (PTH), along with 24-hour urine values (calcium, oxalate, citrate, uric acid, volume, and pH), were recorded. The study primarily compares metabolic differences between:
First-time vs. recurrent stone formers
COM vs. COD stone subtypes
Findings from this study are expected to improve understanding of metabolic risk factors and contribute to the development of tailored metabolic evaluations and dietary or pharmacological preventive strategies for recurrent stone formers.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| First-time Stone Formers | Other: Metabolik taş analizi ile retrospektif gözlem | Adult patients who presented with their first episode of kidney stone disease. These patients underwent stone composition analysis via FTIR spectroscopy and metabolic evaluation including serum and 24-hour urine testing to identify risk factors for initial stone formation. | |
| Recurrent Stone Formers | Other: Metabolik taş analizi ile retrospektif gözlem | Patients with a documented history of recurrent kidney stone episodes. These individuals were evaluated to assess differences in metabolic profiles and stone composition compared to first-time stone formers, with the aim of identifying predictors of recurrence and optimizing preventive strategies. |
Sex: All, ages: 18 Years to 80 Years
Inclusion Criteria: * Age ≥ 18 years * Patients diagnosed with kidney stones between January 2010 and December 2024 * Stone composition analyzed via Fourier-transform infrared (FTIR) spectroscopy * Available metabolic panel including serum and 24-hour urine values Exclusion Criteria: * Patients with secondary hyperparathyroidism, renal tubular acidosis, or other systemic metabolic diseases affecting stone formation * Patients with incomplete medical records * Patients with non-calcium-based stones (e.g., uric acid, struvite, cystine)