Accelerated Orthodontics With Alveolar Decortication Plus CGF Injection

NCT06975358 — Not applicable, Recruiting, 24 participants, Safa Basiouny Alawy

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Impact of Alveolar Decortication Combined With CGF Injection on Acceleration of Maxillary Canine Retraction-A Randomized Clinical Trial

Registry	NCT06975358
Status	Recruiting
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: single, treatment
Enrollment	24 (Estimated)
Sponsor	Safa Basiouny Alawy (Other)
Conditions	Accelerate Tooth Movement
Interventions	Alveolar decortication plus CGF injection, canine retraction without acceleration (Procedure)
Dates	start 2025-05-20, primary completion 2027-02-01 (estimated), completion 2027-03-01 (estimated), first posted 2025-05-16, last updated 2026-09-29
Locations	1 site in Egypt

-Summary

The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration

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+Arms and interventions

Arm	Type	Interventions	Description
Alveolar decortication plus CGF	Experimental	Procedure: Alveolar decortication plus CGF injection	Alveolar decortication followed by submucosal CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine will be randomly assigned to one side of the maxillary arch (experimental) while the other side serve as (control) receiving orthodontic treatment without any additional intervention
Control	Active comparator	Procedure: canine retraction without acceleration	the other side of the maxillary arch will receive the usual orthodontic treatment without any additional intervention

Alveolar decortication plus CGF injection (Procedure): Experimental sides will receive CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine after performing decortication. After administration of local anesthesia, two-line flap will be performed from the mesial surface of the maxillary second premolar to the distal surface of the maxillary canine Mucoperiosteal flap will be reflected in the buccal side. Two millimeters of marginal crestal bone will be held intact and using a high-speed drill and a round carbide bur (1mm diameter) under copious saline irrigation, the cortical wall will be penetrated to reach marrow spaces. Multiple perforations (10 holes for standardization) in the cortical bone will be created. The surgical site will then rinsed, and the flap will be repositioned and sutured.
canine retraction without acceleration (Procedure): in the control side, the maxillary canine will be retracted without any acceleration procedure

+Outcome measures

Primary outcomes

rate of canine retraction [4 months]

+Eligibility

Sex: All, ages: 16 Years to 22 Years

Inclusion Criteria:

1. Age of the patients ranged from 16: 22 years old.
2. Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
3. Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
4. Good oral hygiene and periodontal condition.

Exclusion Criteria:

1. Medically compromised patients.
2. Severe crowding in the maxillary arch.
3. Chronic intake of NSAIDs or any medication that interfere with OTM.
4. Previous orthodontic treatment.

+Locations (1)

Facility	City	Country	Status
Tanta University	Tanta, Tanta	Egypt	Recruiting

My Notes

Public

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