Combination Therapy of Imiquimod 5%Cream and Cryotherapy vs Monotherapy for Common Warts:Randomized Comparative Trial.

NCT06973473 — Not yet recruiting, 60 participants, Assiut University

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Aprospective,Randomized,Comparative Clinical Trial of Combination Therapy of Imiquimod 5%Cream and Cryotherapy vs Monotherapy for Common Warts.

Registry	NCT06973473
Status	Not yet recruiting
Study type	Observational
Enrollment	60 (Estimated)
Sponsor	Assiut University (Other)
Conditions	Warts
Dates	start 2025-07-01 (estimated), primary completion 2026-07-01 (estimated), completion 2026-08-01 (estimated), first posted 2025-05-15, last updated 2025-05-15

-Summary

To assess the clinical efficacy and safety of topical imiquimod 5% cream combined with cryotherapy versus either of theme alone for the treatment of common warts by clinical and dermoscopic assessments.

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+Detailed description

Topical Imiquimod 5% cream Combined with Cryotherapy Versus either of them alone in Treatment of Common Warts: A prospective Randomized Comparative Trial

+Outcome measures

Primary outcomes

Complete clearance rate of common warts. [12 weeks]: Assessment of complete warts clearance rate at 12weeks to evaluate the efficacy of combination therapy ( imiquimod5%cream+cryotherapy ) compared to topical imiquimod5%cream alone or cryotherapy alone in patients with common wart.

+Eligibility

Sex: All, ages: 18 Years to 60 Years, accepts healthy volunteers

Inclusion Criteria:

* Patients with common warts diagnosed clinically and by dermoscopy.
* Patients older than 18years old.

Exclusion Criteria:

* Pregnancy and lactation.
* Immunosuppression or being under any kind of treatment causing
* absolute or relative immunosuppression.
* Patients with chronic systemic diseases.
* All cases of bleeding tendency or using anticoagulants.
* Concurrent use of systemic or topical treatments of warts in the last 4 weeks.