Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia

NCT06921187 — Not applicable, Not yet recruiting, 110 participants, Institut Pasteur

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Etude de la Perception Auditive après Exposition PROgressive Aux Sons Aversifs Chez Des Personnes MISophonEs

RegistryNCT06921187, acronym PROMISE
StatusNot yet recruiting
PhaseNot applicable
Study typeInterventional; non randomized, parallel, masking: none, basic science
Enrollment110 (Estimated)
SponsorInstitut Pasteur (Industry); collaborators: Institut de l'Audition
ConditionsMisophonia
InterventionsPsychoacoustic test, semi-structured interviews, Exposure to unpleasant sounds (Behavioral, other)
Datesstart 2025-06-01 (estimated), primary completion 2026-03-01 (estimated), completion 2026-03-01 (estimated), first posted 2025-04-10, last updated 2025-04-10
Locations2 sites in France

Related Papers Related Patents Related Grants Related Experts
All trials for Misophonia All trials of Psychoacoustic test All trials of semi-structured interviews

-Summary

The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.

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+Arms and interventions

ArmTypeInterventionsDescription
Control groupActive comparatorBehavioral: Psychoacoustic test; Other: semi-structured interviews
Misophonia groupExperimentalBehavioral: Psychoacoustic test; Other: semi-structured interviews; Other: Exposure to unpleasant sounds
  • Psychoacoustic test (Behavioral): Natural sounds will be presented at different decibels (dB), and the subject will be asked to rate the pleasantness/unpleasantness of the sound heard on a visual analogue scale, as well as the loudness (subjective intensity) of the sound heard.
  • semi-structured interviews (Other): interview, designed under the supervision of a psychologist and using the methodology of micro-phenomenological interviews the aim of these interviews is to gain access to the participants' experiences, as they describe them in the first person, during misophonic episodes
  • Exposure to unpleasant sounds (Other): Home exposure is a practice whereby participants voluntarily subject themselves to SMs in a controlled environment. Participants will be asked to complete two tasks: firstly, they will have to expose themselves to all 10 sounds at least twice a week; secondly, they will have to record the annoyance felt for each sound and the subjective loudness (loudness) of each SM using VAS.

+Outcome measures

Primary outcomes

  • score on a visual analogue scale from 0 (pleasant sound) to 10 (unpleasant sound) [1 week after enrollment]: sounds will be presented at different decibels and the subject will be asked to rate the pleasantness/unpleasantness of the sound on a visual analogue scale
  • score on a visual analogue scale from 0 (very low intensity) to 10 (extremely intense) [1 week after enrollment]: sounds will be presented at different decibels and the subject will be asked to rate the intensity of the sound on a visual analogue scale

Secondary outcomes

  • Measuring the consistency of the psychoacoustic test [1 week after enrollement]: consistency measured by calculating Cronbach's alpha coefficient
  • the number of redundant themes in the semi-structured interviews [1 month after enrollment]: the interviews consist of open-ended questions covering different aspects of the experiences of misophone subjects
  • score on a visual analogue scale from 0 (very little discomfort) to 10 (extreme discomfort) [1 month after enrollment and 2 months after enrollment]

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

For all participants

* Obtain oral consent from the participant after receiving information about the study,
* Be 18 years or older on the day of inclusion,
* Be fluent in French (spoken and written),
* Have no known hearing loss, verified by pure tone audiometry.
* Declare that they do not have tinnitus,
* Declare that they do not have hyperacusis, verified by measuring discomfort thresholds.
* Be affiliated to the social security or equivalent scheme.

For participants with misophonia:

\- Declare discomfort, reduced tolerance to specific sounds (mouth noises, throat clearing, breathing, etc.).

Exclusion Criteria:

* Bear the after-effects of an ear infection and/or have a history of an ENT disease that permanently affects hearing or balance (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis),
* Be under guardianship,
* deprived of liberty by judicial or administrative decision, or subject to legal protection.

+Locations (2)

FacilityCityCountryStatus
Centre de Recherche en Psychologie et Neuroscience (CRPN)MarseilleFrance
CEntre de Recherche et d'Innovation en Audiologie HumaineParisFrance