Interleukin-4 in Pityriasis Lichenoides Chronica

NCT06889506 — Not applicable, Not yet recruiting, 50 participants, Cairo University

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Assessment of Interleukin-4 Tissue and Serum Levels in Pityriasis Lichenoides Chronica Patients : a Case- Control Study

Registry	NCT06889506
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; non randomized, parallel, masking: none, diagnostic
Enrollment	50 (Estimated)
Sponsor	Cairo University (Other)
Conditions	Pityriasis Lichenoides
Interventions	skin biopsy and serum sample (Procedure)
Dates	start 2025-04-01 (estimated), primary completion 2025-07-01 (estimated), completion 2025-07-01 (estimated), first posted 2025-03-21, last updated 2025-03-21

-Summary

assessment of the level of interleukin 4 (IL-4) in the lesional skin and serum of PLC patients and compare its level with healthy controls.

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+Detailed description

measuring the level of Interleukin 4 in lesional skin and it's serum level using ELIZA in patients with Pityriasis lichenoides chronica and comparing the levels with healthy controls levels

+Arms and interventions

Arm	Type	Interventions	Description
PLC patients	Active comparator	Procedure: skin biopsy and serum sample	one skin biopsy (lesional) and serum sample will be taken from every patient
healthy controls	Experimental	Procedure: skin biopsy and serum sample	a skin biopsy and serum sample will be taken from each control sample

skin biopsy and serum sample (Procedure): skin biopsy from lesional skin and serum sample will be taken from each patient . also a skin biopsy and serum sample will be taken from each healthy control

+Outcome measures

Primary outcomes

Assessment of tissue and serum levels of interleukin 4 (IL -4) in pityriasis lichenoides chronica (PLC) patients and normal controls. [6 months]: measurement of tisssue and serum levels of interleukin 4 (IL -4) in pityriasis lichenoides chronica (PLC) patients and comparing them with normal controls to control and verify the hypothesisof involvement of IL-4 in the pathogenesis of PLC

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Patients with pityriasis lichenoides Chronica (PLC): either with the classical presentation papular or hypo-pigmented macules and patches that proved histopathologically to be PLC.
* Both genders
* Age group ≥ 8 years

Exclusion Criteria:

* Patients with other skin diseases
* Patient received treatment for PLC within period less than three months
* Pregnant patients
* Lactating patients