Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate

NCT06730516 — Early Phase 1, Completed, 56 participants, Zagazig University

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Optic Nerve Head Perfusion Following Treatment with Latanoprost 0.005% Versus Brimionidin Tartrate 0.2% in Primary Open Angle Glaucoma: an Optical Coherence Tomography Angiography Study

Registry	NCT06730516
Status	Completed
Phase	Early Phase 1
Study type	Interventional; randomized, parallel, masking: quadruple, treatment
Enrollment	56 (Actual)
Sponsor	Zagazig University (Other gov)
Conditions	Glaucoma
Interventions	Latanoprost (Xalatan), Brimonidine 0.2 % (Drug)
Dates	start 2024-06-24, primary completion 2024-09-01, completion 2024-10-01, first posted 2024-12-12, last updated 2024-12-12
Locations	1 site in Egypt

-Summary

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+Detailed description

This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral POAG equally divided into two groups with 28 patients in each group. The whole VD was increased and also increased in all four nasal, temporal, superior, and inferior quadrants around optic disc from the initial vessel density before treatment (p<0.001) in both groups significantly with superior improvement in group (1) compared to group (2) that was statistically significant

+Arms and interventions

Arm	Type	Interventions	Description
Latanoprost (Xalatan)	Experimental	Drug: Latanoprost (Xalatan)	Group (1) included 23 patients (46 eyes) treated with Latanoprost 0.005 %
Brimonidine 0.2%	Experimental	Drug: Brimonidine 0.2 %	24 patients (48 eyes) received treatment with Brimonidin tartrate 0.2% in group (2)

Latanoprost (Xalatan) (Drug): latanoprost 0.005
Brimonidine 0.2 % (Drug): Brimonidine0.2

+Outcome measures

Primary outcomes

OPTIC NERVE PERFUSION using OCT angiography numerical analysis system presented in % [3 months]: perfusion of optic nerve head in patients with primary open angle glaucoma (POAG) using optical coherence tomography angiography (OCTA).

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* age more than 18 years newly diagnosed naive patients with POAG

Exclusion Criteria:

* optic nerve lesions other than glaucomatous changes patients with previous glaucoma surgery

+Locations (1)

Facility	City	Country	Status
Zagazig University	Zagazig, Sharqia Province	Egypt

+Investigators

Yasmine A Deiaeldin, MD, Study director, Zagazig University
Hani elbialy, MD, Study director, Zagazig University