Effect of Captopril on GLS in Duchenne Myodystrophy

NCT06485661 — Early Phase 1, Unknown, 20 participants, Ain Shams University

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Intermediate Term Effect of Captopril on Left Ventricle Global Longitudinal Strain in Patients With Duchenne Myodystrophy

Registry	NCT06485661
Status	Unknown
Phase	Early Phase 1
Study type	Interventional; na, single group, masking: none, treatment
Enrollment	20 (Estimated)
Sponsor	Ain Shams University (Other)
Conditions	Effect of Drug
Interventions	Captopril Tablets (Drug)
Dates	start 2024-01-01, primary completion 2024-09-30 (estimated), completion 2024-09-30 (estimated), first posted 2024-07-03, last updated 2024-07-16
Locations	1 site in Egypt

-Summary

To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)

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+Detailed description

ACEI slowing down the onset and the progression of dystrophinopathic cardiomyopathy.

+Arms and interventions

Arm	Type	Interventions	Description
Duchenne patients subjected to captopril	Other	Drug: Captopril Tablets

Captopril Tablets (Drug): Patients will be given captopril to see effect on global longitudinal strain

+Outcome measures

Primary outcomes

The impaired global longitudinal strain will change in echo in the number of participants with duchenne myodystrophy [6 months]: Impaired Global longitudinal strain will be changed in echo after 6 months of treatment with Captopril in patients with duchenne myodystrophy

+Eligibility

Sex: Male, ages: 6 Years to any

Inclusion Criteria:

* Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS < -18% with minimum age of 6 years old.

Exclusion Criteria:

* Any patient who refuses to sign an informed consent.
* Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.
* Reduced ejection fraction below 50%.

+Locations (1)

Facility	City	Country	Status
Ain Shams university	Cairo	Egypt	Recruiting

+Investigators

Mona Mostafa Rayan, MD, Principal investigator, Professor of cardiology -Ain Shams university