| Registry | NCT06457646 |
|---|---|
| Status | Unknown |
| Study type | Observational |
| Enrollment | 169 (Estimated) |
| Sponsor | University of Monastir (Other) |
| Conditions | Bruxism |
| Interventions | Genetic polymorphism (Genetic) |
| Dates | start 2024-06-02 (estimated), primary completion 2024-12-15 (estimated), completion 2024-12-17 (estimated), first posted 2024-06-13, last updated 2024-06-13 |
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All trials for Bruxism All trials of Genetic polymorphism
The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are:
* Is there a significant association between the rs6313 polymorphism of the HTR2A gene and bruxism?
* Is there a significant association between the rs6280 polymorphism of the DRD3 gene and bruxism?
Participants will:
Provide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms.
Provide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.
Sex: All, ages: 18 Years to 60 Years, accepts healthy volunteers
Inclusion Criteria: * be above 18 years of age and have a confirmed diagnosis of bruxism Exclusion Criteria: * Systemic diseases, * orofacial dysfunction, * acute symptoms such as neurodegenerative diseases (specifically Parkinsons disease), * Taking medication such as anxiolytics