Autologous Tumor-Infiltrating Lymphocyte (GT307) for Treatment of Patients With Solid Tumours

• GT307 injection (Biological): GT307 injection to treat solid tumours

Primary outcomes

• Incidence and severity of adcersed events per CTCAE 5.0 [3 years]: To characterize the safety profile of autologous TIL injection（GT307) in patients with relapsed/metastatic advanced solid tumor as measured by the incidence and severity of adcersed events per CTCAE 5.0
• Objective response rate [3 years]: To evaluate efficacy parameters such Objective Response Rate (ORR) per RECIST 1.1, as assessed by the Investigator

Sex: All, ages: 18 Years to 70 Years

Inclusion Criteria:

* 1\. Voluntarily join the study, signed informed consent form， willing and able to comply with the study protocol;
* 2\. Age 18 to 70 years old;
* 3\. Ovarian cancer that progresses after recurrence or first-line chemotherapy；
* 4\. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1;
* 5\. Expected survival time of ≥ 12 weeks;
* 6\. Good function of vital organs;
* 7\. Subjects entering this study due to disease progression must have an imaging record of disease progression before tumor sampling;
* 8\. At least one measurable target lesion that meets the definition of RECIST v1.1 after tumor sampling.

Exclusion Criteria:

* 1.Patients with uncontrollable tumor-related pain as judged by the investigator; participants requiring analgesic medication must already have a stable analgesic regimen at the time of study entry; symptomatic lesions suitable for palliative radiotherapy should be completed prior to study entry;
* 2.Known mental illness, alcoholism, drug use or substance abuse;
* 3.Pregnant or lactating women; or women who are pregnant, breastfeeding, or planning to become pregnant within 1 year after cell infusion;
* 4.Those who have received other clinical trial drug treatment within 4 weeks before preconditioning by lymphodepletion,plan to participate in other clinical trial drug treatment during the study;
* 5.The investigators determine that other conditions that make the patient not suitable for enrollment.