Clinico-biological Collection of Bone, Calcium and Growth Plate Pathologies

NCT06444503 — Recruiting, 350 participants, University Hospital, Toulouse

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Creation of a Biological Collection to Study the Pathophysiology and Identify Predictive Factors for the Evolution of Bone, Calcium and Growth Plate Pathologies

Registry	NCT06444503, acronym OSCAR
Status	Recruiting
Study type	Observational
Enrollment	350 (Estimated)
Sponsor	University Hospital, Toulouse (Other)
Conditions	Bone Disorder
Interventions	Biological samples, Biological (Other)
Dates	start 2024-09-16, primary completion 2034-09-16 (estimated), completion 2034-09-16 (estimated), first posted 2024-06-05, last updated 2026-06-05
Locations	1 site in France

-Summary

The aim of this project is to set up a biological and clinical collection of patients with progressive bone, calcium and growth plate pathologies.

This collection will provide a better understanding of the mechanisms involved in growth plate and bone damage in these diseases and identify factors predictive of progression and new therapeutic targets.

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+Arms and interventions

Arm	Type	Interventions	Description
Patients suffering from growth plate or bone pathology		Other: Biological samples; Other: Biological	As part of their pathology, patients benefit from clinical monitoring and regular blood and urine tests.

Biological samples (Other): Blood and urine will be taken in larger quantity
Biological (Other): Surgical residues may be preserved in the event of surgery carried out as part of the treatment.

+Outcome measures

Primary outcomes

Building a collection of biological samples and clinical-biological data from patients presenting bone, calcium and growth plate pathologies [Day 0 and through study completion, an average of 5 years]: Blood and urine sampling

Secondary outcomes

Identification of potential markers of disease progression based on new knowledge. [Day 0 and through study completion, an average of 5 years]

+Eligibility

Sex: All, ages: any to 99 Years

Inclusion Criteria:

* Children (from birth) with growth plate or bone pathology
* Patients affiliated to or benefiting from a social security scheme
* Patients able to receive information about the study and to understand the information form in order to participate in the study. This implies :
* mastery of the French language
* Not being subject to a restriction of rights by the judicial authorities
* Patients or legal representatives having given their consent to participate in the study (expression of non-opposition).

Exclusion Criteria:

* Patients under legal protection (guardianship, curatorship or safeguard of justice)
* Pregnant or breast-feeding women

+Locations (1)

Facility	City	Country	Status
University Toulouse Hospital	Toulouse	France	Recruiting

+Investigators

Thomas EDOUARD, MD, Principal investigator, University Hospital, Toulouse