Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study

NCT06405919 — Completed, 160 participants, University of Khartoum

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Registry	NCT06405919
Status	Completed
Study type	Observational
Enrollment	160 (Actual)
Sponsor	University of Khartoum (Other); collaborators: Sudan Medical Specialization Board
Conditions	Incidence of Thyroid Cancer in Long Standing MNG
Interventions	Histopathology (Diagnostic test)
Dates	start 2017-03-01, primary completion 2018-09-30, completion 2018-09-30, first posted 2024-05-09, last updated 2024-05-09
Locations	1 site in Sudan

-Summary

To determine the incidence of thyroid cancer in patients with long standing goitres presenting for surgery.

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+Detailed description

This is a prospective cohort study The objective is to determine the incidence of cancer in patients with long standing goitres( more than 10 years ) who present for surgery in Khartoum Teaching Hopspital - Sudan.

Introduction: goitre is endemic in Sudan with prevalence ranging between 5-42% in different regions of the country. Patients are referred for surgery only if they develop pressure symptoms.

The incidence of thyroid carcinoma is high in endemic goitrous areas. Determining the risk of cancer in patient with long standing goitres may help in early early referral and early surgical intervention.

Methods: This is prospective cohort study including 160 patients with long standing goitrers of 10 years or more who presented from March 2017 to September 2017 to Khartoum Teaching Hospital-Sudan

+Arms and interventions

Arm	Type	Interventions	Description
Patients with goitres 10 years or more		Diagnostic Test: Histopathology	Patients with long standing multinodular goitres of 10years or more presenting to surgical unit in Khartoum Teaching Hospital -Sudan. Checking incidence of malignancy in this group.

Histopathology (Diagnostic test): Thyroidectomy for patients and histological examination of specimen to determine incidence of malignancy.

+Outcome measures

Primary outcomes

Rate of malignancy [March 2017-September 2018]: Rate of malignancy in resected goitre specimens

+Eligibility

Sex: All

Inclusion Criteria:

* All patients with long standing goitres of 10 years or more

Exclusion Criteria:

* Non

+Locations (1)

Facility	City	Country	Status
Faculty of Medicine University of Khartoum	Khartoum	Sudan

+Investigators

Mohamed Elmakki Abdella, MS,FRCSI, Study director, University of Khartoum -Faculty of Medicine