Differential Expression and Potential Value of c-MYC in Non-invasive and Invasive Mammary Carcinoma
| Registry | NCT06357338 |
|---|---|
| Status | Unknown |
| Study type | Observational |
| Enrollment | 70 (Estimated) |
| Sponsor | Marwa Mahmoud Hassan (Other); collaborators: Qena Oncology Center |
| Conditions | Invasive Breast Cancer |
| Interventions | no intervention (Other) |
| Dates | start 2024-03-19, primary completion 2025-04-01 (estimated), completion 2026-04-01 (estimated), first posted 2024-04-10, last updated 2024-04-10 |
| Locations | 1 site in Egypt |
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Retrospective observational study to evaluate c-MYC expression in non invasive and invasive mammry carcinoma
To correlate different levels of c-MYC expressions with variable clinical and pathological parameters of mammary carcinoma (such as patients' ages, tumor grading, staging, laterality, focality and nodal metastasis, co-existing in-situ components). This study will be carried out on archived formalin-fixed and paraffin embedded tissue blocks that were belonged to 70 women with breast lumps.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| non invasive mammary carcinoma | Other: no intervention | 35 cases with non invasive breast cancer with low and high nuclear grades and co existing microfoci of invasion | |
| invasive mammary carcinoma | Other: no intervention | 35 cases of invasive breast cancer undergone MRM and classify them according grading, staging and luminal subtypes |
Sex: Female, ages: 15 Years to any
Inclusion Criteria: Specimens of Modified Radical Mastectomies from breast carcinoma patients Exclusion Criteria: * Cases with insufficient clinical data. * Tissue blocks of destroyed or insufficient material, unfit for diagnosis. * Cases who received pre-operative chemotherapy.
| Facility | City | Country | Status |
|---|---|---|---|
| Sohag university | Sohag | Egypt |