Evaluation of Human Efficacy of SOD Like Super Drink

• SOD like Super Drink (Dietary supplement), also known as AVON SOD like Super Drink: consume 1 bottle per day
• placebo drink (Dietary supplement): consume 1 bottle per day

Primary outcomes

• the volume of skin wrinkles [Volume change from Baseline skin wrinkles at 8 weeks]: IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units
• the roughness of skin texture [Rating skin roughness from Baseline skin texture at 8 weeks]: IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units
• the change of skin elasticity [Change from Baseline skin elasticity at 8 weeks]: Cutometer® was utilized to measure skin elasticity. Units: arbitrary units
• the change of Total Anti-oxidative Capacity (TAC) of blood [Change from Baseline TAC at 8 weeks]: venous blood was sampled to measure TAC
• the change of Superoxide Dismutase (SOD) of blood [Change from Baseline SOD at 8 weeks]: venous blood was sampled to measure SOD
• the change of Glutathione S-transferase (GST) of blood [Change from Baseline GST at 8 weeks]: venous blood was sampled to measure GST
• the change of Glutathione (GSH) of blood [Change from Baseline GSH at 8 weeks]: venous blood was sampled to measure GSH
• the change of Malondialdehyde (MDA) of blood [Change from Baseline MDA at 8 weeks]: venous blood was sampled to measure MDA
• the change of immune-related cytokines of blood [Change from Baseline immune-related cytokines at 8 weeks]: venous blood was sampled to measure immune-related cytokines

Secondary outcomes

• the change of skin surface hydration [Change from Baseline skin surface hydration at 8 week]: Corneometer® CM 825 was utilized to measure skin surface hydration. Units: arbitrary units
• the change of skin Transepidermal Water Loss (TEWL) [Change from Baseline TEWL at 8 week]: Tewameter® TM 300 was utilized to measure TEWL. Units: arbitrary units
• the change of Skin Melanin Index [Change from Baseline skin Melanin Index at 8 week]: Mexameter® MX 18was utilized to measure Melanin Index. Units: arbitrary units
• the change of Skin Erythema Index [Change from Baseline skin Erythema Index at 8 week]: Mexameter® MX 18was utilized to measure skin Erythema Index. Units: arbitrary units

Other outcomes

• The change of liver function biomarkers (AST, ALT) of blood [Change from Baseline liver function biomarkers at 8 weeks]: Venous blood was sampled to measure liver function biomarkers
• The change of renal function biomarkers (creatinine, BUN) of blood [Change from Baseline renal function biomarkers at 8 weeks]: Venous blood was sampled to measure renal function biomarkers
• The change of self-assessment skin condition and immuno condition [Change from Baseline skin condition and immunol condition at 8 weeks]: A self-assessment questionnaire was collected to evaluate skin condition and immunol condition，As for the evalutation of skin condition ,the higher score the better；As for evaluation of immunol condition , the higher score the worse

Sex: All, ages: 30 Years to 65 Years, accepts healthy volunteers

Inclusion Criteria:

* healthy adults aged between 30-65 years old

Exclusion Criteria:

* Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder
* Patients with diseases of the skin, liver, kidney.
* Female who is pregnant or nursing or planning to become pregnant during the course of the study.
* Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
* Students who are currently taking courses taught by the principal investigator of this trial.

• Hsiu-Mei Chiang, Principal investigator, China Medical University of department of cosmeceutics