Perioperative Factors and Early Postoperative Kidney Graft Function Recovery

NCT06280898 — Completed, 539 participants, Seoul St. Mary's Hospital

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Analysis of Perioperative Factors Affecting Early Postoperative Kidney Graft Function Recovery in Patients Undergoing Living Kidney Transplant Surgery

Registry	NCT06280898
Status	Completed
Study type	Observational
Enrollment	539 (Actual)
Sponsor	Seoul St. Mary's Hospital (Other)
Conditions	Heart Injuries, Kidney Transplant; Complications
Interventions	Remote ischemic conditioning (Procedure)
Dates	start 2020-05-01, primary completion 2022-03-14, completion 2022-03-14, first posted 2024-02-28, last updated 2024-02-29
Locations	1 site in South Korea

-Summary

Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE), or Kidney Disease: Improving Global Outcomes (KDIGO) I would like to divide it according to the definition. After testing the normal distribution of patients, donors, grafts, types of immunosuppressants, surgery/anesthesia factors, and blood test findings between the two groups through the Shapiro-Wilk test, continuous data was tested using the student t-test or Mann-Whitney U test. Sizes are compared using , and categorical data is compared with proportions using the χ2 test or Fisher's exact test. Analysis of factors related to acute kidney injury will be performed through univariate and multivariate logistic regression analysis.

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+Arms and interventions

Arm	Type	Interventions	Description
nonischemic
ischemic		Procedure: Remote ischemic conditioning

Remote ischemic conditioning (Procedure): Remote ischemic condition

+Outcome measures

Primary outcomes

Troponin I [up to 24 hour postoperatively]: Troponin I difference in two groups

Secondary outcomes

Troponin T [up to 24 hour postoperatively]: Troponin T difference in two groups
QTc interval [up to 24 hour postoperatively]: OTc interval difference in two groups

+Eligibility

Sex: All, ages: 19 Years to 80 Years

Inclusion Criteria:

* Adult patients aged 19 years or older who underwent kidney transplant surgery in the operating room

Exclusion Criteria:

* Pediatric patients under 19 years of age
* Patients with multiple organ transplants, including kidney transplants
* Patients undergoing re-kidney transplant surgery
* Patient examination findings missing from electronic medical record

+Locations (1)

Facility	City	Country	Status
Seoul St. Mary's hospital	Seoul	South Korea