Serum Elafin: A Biomarker in Behcet Disease and Its Relation to Vascular Involvement and Disease Activity
| Registry | NCT06272929 |
|---|---|
| Status | Unknown |
| Study type | Observational |
| Enrollment | 90 (Estimated) |
| Sponsor | Assiut University (Other) |
| Conditions | Behcet Disease and Vascular Affection |
| Interventions | doppler ultrasound (Device) |
| Dates | start 2024-03-01 (estimated), primary completion 2025-03-01 (estimated), completion 2025-04-01 (estimated), first posted 2024-02-22, last updated 2024-02-22 |
Related Papers Related Patents Related Grants Related Experts
All trials for Behcet Disease and Vascular Affection All trials of doppler ultrasound
To measure the level of serum elafin in patients with BD. To assess the relation between serum elafin levels and disease activity. To evaluate the vascular complications in BD and determine their relationship with disease activity.
To assess the correlation between serum elafin and vascular affection and their relation with disease activity.
Behçet's disease (BD) is a chronic, multisystemic, inflammatory disease characterized by recurrent oral and genital ulcers and multiple systemic involvements. Elafin is a serine protease inhibitor produced mainly by epithelial cells. Its expression is upregulated by proinflammatory cytokines such as IL-1β and TNF-α that are potent stimulants of neutrophil activation, it counteracts the destructive effects of neutrophil elastase .Interestingly, previous reports documented the role of serum elafin in the pathogenesis of BD.In fact, vascular complications may be one of the earliest manifestations leading to the diagnosis of BD. There is no reliable tool to identify vascular wall inflammation in BD, except for detecting intravascular thrombosis with ultrasonography (US). Previous studies investigated arterial vessel wall thickness with US (mostly in carotid arteries) in BD . Venous wall inflammation presents with deep vein thrombosis and superficial thrombophlebitis . It was stated that lower extremity vein wall thickness (VWTs)was increased in BD patients independently of vascular activity and important in the diagnosis . However, studies in the literature evaluated only lower extremity VWTs, whereas the relationship of VWT with disease activity has not been emphasized .
| Arm | Type | Interventions | Description |
|---|---|---|---|
| 45 patients with behcet disease | Device: doppler ultrasound | ||
| 45 healthy participants | Device: doppler ultrasound |
Sex: All, ages: 20 Years to 45 Years
Inclusion Criteria: Patients diagnosed as BD. Age of all participants (20-45) years. Exclusion Criteria: Age <20 or >45 years. Other autoimmune diseases. Cardiovascular diseases (heart failure, myocardial ischemia). Possible related risk factors (e.g. diabetes, dyslipidemia, smoking). chronic conditions (e.g. chronic kidney disease, malignancy, autoimmune diseases).