Contained Hepatic Vascular Injuries Following Liver Trauma

NCT06249646 — Completed, 318 participants, Centre Hospitalier Universitaire de Nice

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Contained Hepatic Vascular Injuries Following Liver Trauma: a Retrospective Monocentric Study and Review of the Literature

Registry	NCT06249646
Status	Completed
Study type	Observational
Enrollment	318 (Actual)
Sponsor	Centre Hospitalier Universitaire de Nice (Other)
Conditions	Hepatic Injury, Liver Injury, Pseudoaneurysm
Dates	start 2022-01-01, primary completion 2022-10-31, completion 2023-03-31, first posted 2024-02-08, last updated 2024-02-08
Locations	1 site in France

-Summary

Background: For thirty years, a major shift in the management of liver trauma has been seen. Contained hepatic vascular injuries (CHVI), including pseudo aneurysms and arteriovenous fistula, are often feared due to their risk of secondary bleeding. Nonetheless, knowledge of CHVI is scarce and no guidelines on their management have been set. The investigators aimed to validate the risk factors of CHVI, identify associated morbidities, and establish a management protocol.

Study Design: A retrospective study on 318 liver trauma from a level 1 trauma center over the last 15 years, comparing the presence or not of CHVI. Univarious and multivarious analyses were performed. A comparison of the management of CHVI was also performed.

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+Outcome measures

Primary outcomes

Identification of a % of CHVI on the initial or the follow-up Chest-Thorax scans. [6 months]: A junior and a senior radiologist reviewed all initial and follow-up CT scans, blinded from the diagnostic. Contained hepatic vascular injuries (CHVI) was defined as Hepatic Pseudoaneurysm (HPA) and/or arterio-venous fistula (AVF), under the American Association for Surgery of Trauma (AAST) organ injury scale (2018 revision) for liver trauma definition: a contained focal collection of vascular contrast which decreases in attenuation on delayed phase images on contrast-enhanced CT

Secondary outcomes

Investigate the management of CHVI following liver trauma. [6 months]: size in millimeters of pseudoaneurym conducting to angio-embolization

+Eligibility

Sex: All, ages: 15 Years to any

Inclusion Criteria:

* presence of liver trauma
* age above 15 years old
* a full contrast abdominal CT

Exclusion Criteria: none

+Locations (1)

Facility	City	Country	Status
CHU de Nice	Nice, Alpes Maritimes	France