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Correlation Between Popliteal Vein Compliance and Venous Clinical Severity Score

NCT06175481 — Completed, 173 participants, Hao Liu
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RegistryNCT06175481
StatusCompleted
Study typeObservational
Enrollment173 (Actual)
SponsorHao Liu (Other)
ConditionsChronic Venous Disease (CVD), Vein Compliance, Venous Clinical Severity Score (VCSS)
InterventionsPopliteal Vein Compliance (Other)
Datesstart 2023-06-01, primary completion 2023-10-01, completion 2023-10-01, first posted 2023-12-19, last updated 2023-12-19
Locations1 site in China

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-Summary

When the liquid flow increases, the luminal caliber's stretching amplitude decreases, leading to a higher hydraulic pressure according to Poiseuille's law. In this study, investigators measured the caliber change of the popliteal vein under a rated pressure gradient and evaluated the relationship between popliteal vein compliance and venous clinical severity score (VCSS).

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+Arms and interventions

ArmTypeInterventionsDescription
control groupOther: Popliteal Vein Compliance
experimental groupOther: Popliteal Vein Compliance
  • Popliteal Vein Compliance (Other): Compliance of the popliteal vein is calculated as the distensibility, with the ratio of functional caliber/native caliber/cuff pressure value ( mmHg-1 ).

+Outcome measures

Primary outcomes

  • Compliance of the popliteal vein [May 2023 to October 2023]: Compliance of the popliteal vein is calculated as the distensibility, with the ratio of functional caliber/native caliber/cuff pressure value

+Eligibility

Sex: All, accepts healthy volunteers

Inclusion Criteria:

* C1 to C6 disease using the CEAP (clinical, etiologic, anatomic, pathophysiologic) classification.

Exclusion Criteria:

* acute or chronic thrombosis of deep veins, previously received intravenous surgery or injection sclerotherapy, ankle brachial index<0.90, and concomitant cardiovascular, pulmonary, renal, or metabolic diseases.

+Locations (1)

FacilityCityCountryStatus
Hao LiuGuangzhou, GuangdongChina

+Publications

  • Results publication: Liu H, Li L, Wei W, Tang Y, Liu L, Xiao C. Correlation between popliteal vein functional diameter and the severity of chronic venous disease. Phlebology. 2025 Jul;40(6):415-419. doi: 10.1177/02683555241310531. Epub 2024 Dec 21. PMID 39708049

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