An Investigation of the Effects of a Royal Jelly and Bee Venom-Derived Skin Serum on Skin Health and Signs of Aging

• Manuka Health Eternal Renewal Regenerating Face Serum with Royal Jelly and Bee Venom (Other): Face serum containing manuka honey, royal bee jelly, and bee venom.

Primary outcomes

• Changes in signs of skin health over time assessed via Optic Elite Skin Analysis. [Timeframe: Baseline to Week 8] [8 weeks]: The Optic Elite skin analysis system clinically measures the surface and subsurface layers of skin using digital imaging technology

Secondary outcomes

• Changes in self-perceived appearance of fine lines and wrinkles. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin clarity. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin hydration. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin texture. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin hyperpigmentation. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin irritation. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin brightness. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.
• Changes in self-perceived skin tone evenness. [Timeframe: Baseline to Week 8] [8 weeks]: Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

Sex: Female, ages: 40 Years to 55 Years, accepts healthy volunteers

Inclusion Criteria:

* Female.
* 40-55 years of age.
* Must be in good general health.
* Must have concerns with overall skin health and appearance, including:

Fine lines and wrinkles The appearance of dark spots

* Must be using the same cleanser, toner, and moisturizer for at least one month prior to starting the study.
* Must be willing to keep using the same cleanser, toner, and moisturizer for the duration of the study.
* Must not be using oral or topical retinoids.
* In the last three months, has not introduced any new medications or supplements that target skin health.
* Must be willing to comply with the protocol.

Exclusion Criteria:

* Anyone with an allergy to bees or bee products.
* Females who are pregnant or breastfeeding.
* Unwilling to follow the protocol.
* Unwilling to maintain use of the same cleaner, toner, and moisturizer for the duration of the study.
* Currently participating in another study.
* Use of oral or topical retinoids.
* Individuals with cystic acne or otherwise self-reported very acne-prone skin.
* Use of a prescription medication relevant to the skin.
* Anyone undergoing cosmetic procedures during the study, including Botox, laser, or chemical peel treatments.
* Anyone sensitive or allergic to any ingredients found in the products.
* Anyone with severe chronic conditions, including oncological conditions, psychiatric disorders, or diabetes.