Relevance of Reversible Causes During OHCA (Rebecca Study)

NCT05784480 — Not applicable, Active not recruiting, 100 participants, Medical University of Vienna

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Registry	NCT05784480, acronym REBECCA
Status	Active not recruiting
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, diagnostic
Enrollment	100 (Actual)
Sponsor	Medical University of Vienna (Other); collaborators: Seibersdorf Labor GmbH, Ludwig Boltzmann Institute for Digital Health and Prevention
Conditions	Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Arrest
Interventions	Checklist for evaluation of reversible causes (Diagnostic test)
Dates	start 2023-04-01, primary completion 2025-12-31, completion 2026-12-31 (estimated), first posted 2023-03-27, last updated 2026-04-20
Locations	2 sites in Austria

-Summary

Management of the reversible causes in cardiac arrest is fundamental for successful treatment of out-of-hospital cardiac arrests. Point-of-care diagnostics as prehospital emergency ultrasound, blood gas analysis and toxicological screening support the diagnostic process of evaluating potential reversible causes. Digital tools provide support of a structured approach. This study aims to evaluate the frequency of reversible causes during OHCA as well as specific interventions due to these findings. Furthermore, CPR performance (hands-off, ROSC, 30-day mortality) and cognitive load of the prehospital emergency physician will be investigated. In total 100 patients with OHCA will be included in this study. Identification of reversible causes will be performed upon a structured protocol using an interactive checklist. Cognitive load of emergency physician as well as CPR parameter (frequency of reversible causes, hands-off, ROSC, 30-day mortality) will be analysed.

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+Arms and interventions

Arm	Type	Interventions	Description
Evaluation of reversible causes using digital checklist and diagnostic support	Other	Diagnostic Test: Checklist for evaluation of reversible causes

Checklist for evaluation of reversible causes (Diagnostic test), also known as Venipuncture for toxicological screening, Point-of-Care blood gas analysis, Point-of-Care saliva toxicological screen, Point-of-care ultrasound: Prehospital evaluation by checklist and diagnostic testing for reversible causes of OHCA using point-of-care blood gas analysis, saliva toxicological screen and ultrasound and post-hoc toxicological analysis of blood using mass spectrometry

+Outcome measures

Primary outcomes

Frequency of reversible causes in OHCA and alterations of treatment [up to 30 days]: The primary outcome of this study evaluates the frequency of reversible causes during OHCA.

Secondary outcomes

Frequency of ROSC [up to 30 days]: Any prehospital ROSC/sustained ROSC/in-hospital ROSC
30-day mortality [up to 30 days]: rate of mortality within 30 days in case of hospital admission
Hands-off time [During study completion, up to 120 min]: Hands-off time during process of identification of reversible causes
Cognitive load [1 year (evaluation in documentation phase after CPR)]: NASA Task Load Index evaluated by the prehospital emergency physician after rescue mission

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Patients with prehospital cardiac arrest, where POCUS, blood gas analysis as well as screening for intoxication can integrated in ALS rhythm without delay of life-saving treatment or transportation will be included.

Exclusion Criteria:

* Patients will be excluded under the age of 18, or if POCUS, blood gas analysis will lead to a delay of live-saving treatment or transportation. Furthermore, pregnant patients will be excluded.

+Locations (2)

Facility	City	Country	Status
Anesthesiology and Intensive Care Medicine Department - Medical University of Vienna	Vienna	Austria
Department of Anesthesia, General Intensive Care and Pain Management,Medical University of Vienna	Vienna	Austria