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Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism

NCT05774444 — Not applicable, Completed, 52 participants, University of Glasgow

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Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial

RegistryNCT05774444, acronym KIPLING
StatusCompleted
PhaseNot applicable
Study typeInterventional; randomized, parallel, masking: quadruple, treatment
Enrollment52 (Actual)
SponsorUniversity of Glasgow (Other); collaborators: Aker BioMarine
ConditionsHypertrophy
InterventionsKrill oil, Krill protein, Vegetable oil, Carbohydrate (Dietary supplement)
Datesstart 2023-05-01, primary completion 2025-05-25, completion 2025-05-25, first posted 2023-03-17, last updated 2026-04-29
Locations1 site in United Kingdom

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-Summary

The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.

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+Arms and interventions

ArmTypeInterventionsDescription
Vegetable oil + CarbohydratePlacebo comparatorDietary Supplement: Vegetable oil; Dietary Supplement: CarbohydrateThe vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
Vegetable oil + Krill proteinExperimentalDietary Supplement: Krill protein; Dietary Supplement: Vegetable oilThe vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g)
Krill oil + CarbohydrateExperimentalDietary Supplement: Krill oil; Dietary Supplement: CarbohydrateThe Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
Krill oil + Krill proteinExperimentalDietary Supplement: Krill oil; Dietary Supplement: Krill proteinBoth the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)
  • Krill oil (Dietary supplement): Krill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation.
  • Krill protein (Dietary supplement): Krill protein will be given to the participant following a resistance exercise bout.
  • Vegetable oil (Dietary supplement): This will be the control against the Krill oil
  • Carbohydrate (Dietary supplement): This will be the control for the Krill protein

+Outcome measures

Primary outcomes

  • Post-exercise muscle protein synthesis [3-7 hours]: Muscle protein synthesis measured 3-7h after a single bout of resistance exercise

Secondary outcomes

  • Change in Muscle thickness [Change from baseline to 8 weeks]: Vastus lateralis muscle thickness measured by ultrasound
  • Change in grip strength [Change from baseline to 8 weeks]: Grip strength measured with a Jamar dynamometer
  • Change in fat mass [Change from baseline to 8 weeks]: Whole body fat mass measured by BIA
  • Change in lean mass [Change from baseline to 8 weeks]: Whole body lean mass measured by BIA
  • Change in muscle strength [Change from baseline to 8 weeks]: Knee extensor muscle strength measured isometrically
  • Change in Chair rise time [Change from baseline to 8 weeks]: Time taken to get up and down from a chair 5 times
  • Change in balance [Change from baseline to 8 weeks]: Ability to stand for 10 seconds in full tandem, semi-tandem and feet together
  • Change in gait speed [Change from baseline to 8 weeks]: Time taken to walk 4 metres at a normal walking pace
  • Basal muscle protein synthesis [0-3 hours]: Muscle protein synthesis measured from 0-3h after an overnight fast
  • Change in Erythrocyte fatty acid profile [Change from baseline to 8 weeks]: Erythrocyte fatty acid profile

+Eligibility

Sex: All, ages: 60 Years to 90 Years, accepts healthy volunteers

Inclusion Criteria:

* Be 60 years old or older
* Have a BMI of less than 35kg/m2
* Be participating in structured exercise for less than 2h per week

Exclusion Criteria:

* Diabetes
* Severe cardiovascular disease
* Seizure disorders,
* Uncontrolled hypertension (>150/90mmHg at baseline measurement)
* Cancer or cancer that has been in remission <5 years
* Ambulatory impairments which would limit ability to perform assessments of muscle function
* Dementia
* Taking medication known to affect muscle (e.g., steroids)
* Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
* Anticoagulant therapy
* Allergies to seafood
* Regular consumption of more than 1 portion of oily fish per week.

+Locations (1)

FacilityCityCountryStatus
Stuart Robert GrayGlasgowUnited Kingdom

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