Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial
| Registry | NCT05774444, acronym KIPLING |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, parallel, masking: quadruple, treatment |
| Enrollment | 52 (Actual) |
| Sponsor | University of Glasgow (Other); collaborators: Aker BioMarine |
| Conditions | Hypertrophy |
| Interventions | Krill oil, Krill protein, Vegetable oil, Carbohydrate (Dietary supplement) |
| Dates | start 2023-05-01, primary completion 2025-05-25, completion 2025-05-25, first posted 2023-03-17, last updated 2026-04-29 |
| Locations | 1 site in United Kingdom |
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The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Vegetable oil + Carbohydrate | Placebo comparator | Dietary Supplement: Vegetable oil; Dietary Supplement: Carbohydrate | The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) |
| Vegetable oil + Krill protein | Experimental | Dietary Supplement: Krill protein; Dietary Supplement: Vegetable oil | The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g) |
| Krill oil + Carbohydrate | Experimental | Dietary Supplement: Krill oil; Dietary Supplement: Carbohydrate | The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) |
| Krill oil + Krill protein | Experimental | Dietary Supplement: Krill oil; Dietary Supplement: Krill protein | Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g) |
Sex: All, ages: 60 Years to 90 Years, accepts healthy volunteers
Inclusion Criteria: * Be 60 years old or older * Have a BMI of less than 35kg/m2 * Be participating in structured exercise for less than 2h per week Exclusion Criteria: * Diabetes * Severe cardiovascular disease * Seizure disorders, * Uncontrolled hypertension (>150/90mmHg at baseline measurement) * Cancer or cancer that has been in remission <5 years * Ambulatory impairments which would limit ability to perform assessments of muscle function * Dementia * Taking medication known to affect muscle (e.g., steroids) * Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump), * Anticoagulant therapy * Allergies to seafood * Regular consumption of more than 1 portion of oily fish per week.
| Facility | City | Country | Status |
|---|---|---|---|
| Stuart Robert Gray | Glasgow | United Kingdom |