Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

NCT05723796 — Not applicable, Completed, 40 participants, Cairo University
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Study of Nasal Mucosa Histopathological Changes in Patients With Chronic Hypersensitivity Pneumonitis

RegistryNCT05723796
StatusCompleted
PhaseNot applicable
Study typeInterventional; na, single group, masking: none, diagnostic
Enrollment40 (Actual)
SponsorCairo University (Other)
ConditionsHypersensitivity Pneumonitis, Nasal Mucosal Disorder
Interventionsnasal endoscopy (Procedure)
Datesstart 2021-07-01, primary completion 2022-10-31, completion 2022-12-15, first posted 2023-02-13, last updated 2023-02-13
Locations1 site in Egypt

Related Papers Related Patents Related Grants Related Experts
All trials for Hypersensitivity Pneumonitis All trials for Nasal Mucosal Disorder All trials of nasal endoscopy

-Summary

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa.

Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

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+Arms and interventions

ArmTypeInterventionsDescription
chronic HP patientsExperimentalProcedure: nasal endoscopy
  • nasal endoscopy (Procedure): nasal endoscopy and mucosal biopsy

+Outcome measures

Primary outcomes

  • percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy [6 months]: nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations

+Eligibility

Sex: All, ages: 29 Years to 55 Years

Inclusion Criteria:

* all patients with clinical and radiological features of HP

Exclusion Criteria:

* respiratory failure
* patients on anticoagulants

+Locations (1)

FacilityCityCountryStatus
Kasr alainy school of medicineCairoEgypt

+Publications

  • Results publication: Akl Y, Ibrahim EK, Algarf TM, Mostafa RR, Abdel-Hamid HM, Muhammed AI. Study of nasal mucosa histopathological changes in patients with hypersensitivity pneumonitis. Sci Rep. 2023 May 31;13(1):8868. doi: 10.1038/s41598-023-35871-5. PMID 37258647